Compiles DNA sequence polymorphisms (DSPs) that are predicted to perturb miRNA-mediated gene regulation. Distinctive features include: (i) the coverage of seven vertebrate species in its present release, aiming for more when information becomes available, (ii) the coverage of the three compartments involved in the silencing process (i.e. targets, miRNA precursors and silencing machinery), (iii) contextual information that enables users to prioritize candidate 'Patrocles DSPs', including graphical information on miRNA-target coexpression and eQTL effect of genotype on target expression levels, (iv) the inclusion of Copy Number Variants and eQTL information that affect miRNA precursors as well as genes encoding components of the silencing machinery and (v) a tool (Patrocles finder) that allows the user to determine whether her favorite DSP may perturb miRNA-mediated gene regulation of custom target sequences.
Systems and Modeling, Montefiore Institute, University of Liège, Belgium; Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Belgium
Patrocles funding source(s)
European Union’s Framework 6 (Callimir STREP, Epigenome NoE, Eadgene NoE); Belgian Science Policy organisation (SSTC Genefunc, BioMAGNet PAI); Belgian Fonds National de la Recherche Scientifique; Communauté Française de Belgique (Game, BIOMOD ARC); University of Liège