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Patrocles specifications

Information


Unique identifier OMICS_11148
Name Patrocles
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes

Maintainer


  • person_outline Michel Georges

Publication for Patrocles

Patrocles citations

 (25)
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Study of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma

2016
Oncotarget
PMCID: 5190100
PMID: 27259248
DOI: 10.18632/oncotarget.9736
call_split See protocol

[…] FBW7 were selected by bioinformatics data bank using Haploview software, bioinformatics software packages such as TargetScan Human 6.2 (http://www.targetscan.org/), miRanda (http://microrna.org/) and Patrocles (http://www.patrocles.org/) to offer potential miRNA binding sites within the 3′UTRs of these genes. As a result, totally 11 SNPs in these genes were included for further genotyping with the […]

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Predictive role of microRNA related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

2016
Oncotarget
PMCID: 4991418
PMID: 26934318
DOI: 10.18632/oncotarget.7757
call_split See protocol

[…] A set of miRNA-related SNPs potentially impacting miRNA maturation and activity was selected.Patrocles [] and PubMed (www.pubmed.org) websites were used to identify genes involved in miRNA maturation. A set of genes encoding for miRNAs was included in the analysis. The miRNAs were selected ba […]

library_books

Bioinformatic tools for microRNA dissection

2015
Nucleic Acids Res
PMCID: 4705652
PMID: 26578605
DOI: 10.1093/nar/gkv1221

[…] bution to the study of the interplay between SNPs and miRNAs and of their association with disease has come from the creation of online databases and tools (see Table and Supporting Material S2).The Patrocles () database collects DNA sequence polymorphisms in the 3′ UTR of genes that perturb miRNA-mediated gene regulation in seven vertebrate species. It also provides a tool (Patrocles finder) tha […]

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Associations of Il 1 Family Related Polymorphisms With Gastric Cancer Risk and the Role of Mir 197 In Il 1f5 Expression

2015
PMCID: 5058962
PMID: 26632693
DOI: 10.1097/MD.0000000000001982
call_split See protocol

[…] pMap database (http://www.hapmap.org), then we used Haploview software, bioinformatics software packages such as TargetScan Human 6.2 (http://www.targetscan.org/), miRanda (http://microrna.org/), and Patrocles (http://www.patrocles.org/) to select SNPs of the microRNA-binding sites in 3′ UTR region of these genes. As a result, 10 SNPs in these genes were totally included for further genotyping wit […]

library_books

Genetic Variants in MiRNA Processing Genes and Pre MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia

2015
PLoS One
PMCID: 4368096
PMID: 25793711
DOI: 10.1371/journal.pone.0118905

[…] rocles database (http://www.patrocles.org). In each gene, using tagSNPs, we covered almost all the SNPs with potentially functional effects using bioinformatics tools (F-SNP, Fast-SNP, polymirTS [, ] Patrocles [], Hapmap, Haploview). We considered functional effects those causing amino acid changes, alternative splicing, those located in the promoter region in putative transcription factor binding […]

library_books

Genome wide Identification of microRNA Expression Quantitative Trait Loci

2015
Nat Commun
PMCID: 4369777
PMID: 25791433
DOI: 10.1038/ncomms7601

[…] nic non-coding RNA . We also downloaded other regulatory tracks, including experimentally validated miRNA targets from TARbase , and experimentally supported miRNA-mediated gene regulatory sites from Patrocles . Binominal tests were used to evaluate if the identified cis-miR-eQTLs set (5269 cis-miR-eQTLs) showed enrichment for regulatory SNPs for each track (methods described by ).We further deter […]

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Patrocles institution(s)
Systems and Modeling, Montefiore Institute, University of Liège, Belgium; Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Belgium
Patrocles funding source(s)
Supported by European Union’s Framework 6 (Callimir STREP, Epigenome NoE, Eadgene NoE); Belgian Science Policy organisation (SSTC Genefunc, BioMAGNet PAI); Belgian Fonds National de la Recherche Scientifique; Communauté Française de Belgique (Game, BIOMOD ARC); University of Liège.

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