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In a typical proteomic experiment, a huge volume (e.g. 1 GB) of MS data is often generated. Each of MS spectra consists of two large vectors corresponding to mass to charge ratio (m/z) and intensity value, respectively. The first step in proteomic data analysis is to extract peptide induced signals (i.e., peaks) from raw MS spectra. Peak detection is not only a feature extraction step, but also an indispensable step for subsequent protein identification, quantification and discovery of disease-related biomarkers (Gras et al., 1999; Adam et al., 2002). Source text: Yang et al., 2009.