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PepCalc specifications


Unique identifier OMICS_32443
Name PepCalc
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline PepCalc Team

Additional information

PepCalc citations


Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches

PLoS One
PMCID: 5929558
PMID: 29715318
DOI: 10.1371/journal.pone.0196484

[…] creasing the accuracy and validating our study to be taken to the experimental room. Furthermore, we tested our predicted epitopes RREVYDFAF46-54 (Cluster 3) for the optimal peptide properties, using PepCalc, which resulted in promising water solubility and other good experimental properties. Our results showed that combining cluster 3 and cluster 4 will form a continues epitope that will elicit r […]


Method to generate highly stable D amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB

Proc Natl Acad Sci U S A
PMCID: 5816147
PMID: 29378946
DOI: 10.1073/pnas.1711837115

[…] elix. shows that (D)-GLP1 has approximately the same secondary structure profile as (L)-GLP1. An isoelectric point prediction of pH 4.66, and net charge evaluation of −1.9 at pH 7 for (D)-GLP1 using pepcalc (), indicates that it has good solubility and, thus, is suitable for experimental validation. […]


Predicted Release and Analysis of Novel ACE I, Renin, and DPP IV Inhibitory Peptides from Common Oat (Avena sativa) Protein Hydrolysates Using in Silico Analysis

PMCID: 5742776
PMID: 29207547
DOI: 10.3390/foods6120108

[…] study (). Additional in silico analysis was carried out to predict water solubility, resistance to gastrointestinal digestion, toxicity, and allergenicity (). Solubility in water was predicted using PepCalc, which is available at Resistance to digestion was predicted using PeptideCutter, which is available at [] with the enzymes’ chymotryp […]


Peptidomics of an in vitro digested α Gal carrying protein revealed IgE reactive peptides

Sci Rep
PMCID: 5507865
PMID: 28701697
DOI: 10.1038/s41598-017-05355-4

[…] e was set to 0.01 for strict and 0.05 for relaxed mode of peptide discovery. The N-glycosylation sites were mapped based on information from (UniProtKB-P01267). Peptide calculator ( was used for theoretical mass calculation of obtained peptides and Peptide Cutter at ExPASy to map the theoretical pepsin cleavage sites (at Phe, Tyr, Trp and Leu) in the BTG primary str […]


Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin G structure based designed

BMC Neurosci
PMCID: 5433008
PMID: 28511693
DOI: 10.1186/s12868-017-0361-4

[…] ide (EAR7) as control (TKRSSRAFRE), one that was designed to interact with an intracellular site, the C-terminal domain (CTD) of GluN2B subunit []. EAR16 and EAR 18 show good water solubility ( and have similar hydrophobicity levels: 19.36 and 19.65, respectively ( […]


Peptides actively transported across the tympanic membrane: Functional and structural properties

PLoS One
PMCID: 5325213
PMID: 28234923
DOI: 10.1371/journal.pone.0172158

[…] rans-TM transport rate. We also sought to identify unique features of TM-3 and TM-4 that might explain their exponential rate of transport over time, when compared to the remaining selected peptides. Pepcalc analysis () indicated that the two peptides that exhibited exponential increases in transport over time (TM-3 and TM-4) were both characterized by a basic amino acid at position 6, and strongl […]


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