bookmark pyGeno A python package that allows you to easily combine reference genomes and sets of polymorphisms together to create personalized genomes. Personalized genomes can be used to work directly on the genomes of you subjects and be translated into personalized proteomes. Multiple sets of polymorphisms can also be combined together to leverage their independent benefits. Ex: RNA-seq and DNA-seq for the same individual to improve the coverage, RNA-seq of an individual + dbSNP for validation, Combine the results of RNA-seq of several individuals to create a genome only containing the common polymorphisms. pyGeno is also a personal database that give you access to all the information provided by Ensembl (for both reference and personalized genomes) without the need of queries to distant HTTP APIs. It also comes with parsers for several file types and various other useful tools.