PFIM specifications


Unique identifier OMICS_16904
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Medium
Version 4.0
Stability Stable
Maintained Yes



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  • person_outline François Combes <>

Publications for PFIM

PFIM in publications

PMCID: 5110617
PMID: 27804003
DOI: 10.1007/s10928-016-9499-4

[…] block-diagonal fim. the default optimization settings were used and the foce approximation had 4000 conditional samples. the fo optimizations using the full and block-diagonal fim were replicated in pfim 3.2.2 [] with the default optimization search settings for comparison of the optimal designs generated with poped., to evaluate the different designs, stochastic simulation and estimations (sse) […]

PMCID: 4147042
PMID: 25011414
DOI: 10.1208/s12248-014-9641-4

[…] (fig. ). an optimal sampling design with reasonably low expected residual errors should then be obtained by making use of optimal design methodology (e.g. poped: or pfim: subsequently, simulation-based power calculations can be performed to evaluate the sample sizes for different study designs consisting of part densely and part […]

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PFIM institution(s)
IAME UMR 1137, INSERM, Paris, France; IAME UMR 1137, Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Institut Roche de Recherche et Médecine Translationnelle, Boulogne-Billancourt, France; Pharma Research and Early Development, Clinical Pharmacology, F. Hoffmann-La Roche Ltd, Basel, Switzerland
PFIM funding source(s)
Supported by a Convention Industrielle de Formation par la Recherche from the French government and the Institut Roche de Recherche et Médecine Translationnelle.

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