Gathers detailed drug, drug-target, drug action and drug interaction information about drugs. DrugBank is a web resource that contains information about FDA-approved drugs as well as experimental drugs going through the FDA approval process. The database also includes pharmaco-omic data covering the influence of drugs on metabolite levels, gene expression levels and protein expression levels, as well as data on investigational drug clinical trials and drug repurposing trials, and thousands of up-to-date drug images of approved drugs.
A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers. PharmGKB has refocused on curating knowledge rather than housing primary genotype and phenotype data, and now, captures more complex relationships between genes, variants, drugs, diseases and pathways.
A relational database tool for storing, querying, integrating, and downloading molecular profile data on the NCI-60 and other cancer cell types. The newest CellMiner version includes integration of novel databases and tools associated with whole-exome sequencing and protein expression. Included are (i) "Cell line signature" for DNA, RNA, protein, and drugs; (ii) "Cross correlations" for up to 150 input genes, microRNAs, and compounds in a single query; (iii) "Pattern comparison" to identify connections among drugs, gene expression, genomic variants, microRNA, and protein expressions; (iv) "Genetic variation versus drug visualization" to identify potential new drug:gene DNA variant relationships; and (v) "Genetic variant summation" designed to provide a synopsis of mutational burden on any pathway or gene group for up to 150 genes. Together, these tools allow users to flexibly query the NCI-60 data for potential relationships between genomic, molecular, and pharmacologic parameters in a manner specific to the user's area of expertise.
Provides a large-scale pharmacogenomics dataset to link disease-associated transcriptional signatures with chemical and genetic perturbagen-associated transcriptional signatures. Lincscloud is designed to make CMap/LINCS data accessible to a wide audience. It enables integrated analysis of CMap/LINCS datasets across all types of data emerging from L1000/LINCS assays, all types of users - computationalists, biologists, and software engineers, and all types of institutions - data generators, computational centers, non-consortium labs.
Provides an interface for biologists and clinicians working on solid tumors and hematological malignancies. OncoPortal is a platform based on precision medicine intelligence with curated and reliable databases on gene biomarkers and clinical trials. It contains annotations of associations between human gene variants, disease causality, progression and drug efficacy and toxicity. It offers access to somatic classification, specific drug association with the disease and clinical evidence summaries.
Gathers information about in vitro drug screens. PharmacoDB compiles multiple publicly highthroughput cancer pharmacogenomic datasets to highlight drug or cell line of interest. The database supplies access to molecular profiles of cell lines and computational analytical tools via linkage to PharmacoGx, an R/Bioconductor package implementing a suite of statistical modeling functions to jointly analyze molecular features and drug dose-response curves.