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Protocols

PharmGKB specifications

Information


Unique identifier OMICS_02763
Name PharmGKB
Restrictions to use None
Maintained Yes
Wikipedia https://en.wikipedia.org/wiki/PharmGKB

Taxon


  • Primates
    • Homo sapiens

Maintainer


  • person_outline Teri Klein

Publication for PharmGKB

PharmGKB citations

 (79)
library_books

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin Sheng Hua Granule for Treating Anemia

2018
Front Pharmacol
PMCID: 5840524
PMID: 29551975
DOI: 10.3389/fphar.2018.00165

[…] atabase (HIT) () to discover the relevant targets supported by literature. Besides, to better understand the mechanism of XHSG for the treatment of anemia, all obtained targets were also sent to TTD, PharmGKB, and Comparative Toxicogenomics Database (CTD) (; ). And targets which were implicated in the clinical manifestations of anemia were retained, while others were eliminated. Finally, the signa […]

library_books

Pharmacogenomics of GPCR Drug Targets

2018
Cell
PMCID: 5766829
PMID: 29249361
DOI: 10.1016/j.cell.2017.11.033

[…] Clinical information about missense variant-drug pairs with reported changes in efficacy, dosage or toxicity/ADR were manually curated from the literature and PharmGKB, which aggregates the impact of human genetic variation on drug response (https://www.pharmgkb.org/). We obtained the level of evidence for each association as listed in PharmGKB. If it was n […]

library_books

Systems pharmacology analysis of synergy of TCM: an example using saffron formula

2018
Sci Rep
PMCID: 5762866
PMID: 29321678
DOI: 10.1038/s41598-017-18764-2

[…] r vitiligo pathogenesis.The obtained protein targets are then mapped to the UniProt Database (http://www.uniprot.org/) for normalization. Subsequently submitted to the Pharm Gkb Database (https://www.pharmgkb.org/), the Therapeutic Targets Database and the Comparative Toxicogenomics Database (http://www.ctdbase.org/) to remove redundant and erroneous targets to ensure the accuracy of the target da […]

call_split

Dengue virus causes changes of MicroRNA genes regulatory network revealing potential targets for antiviral drugs

2018
BMC Syst Biol
PMCID: 5753465
PMID: 29301573
DOI: 10.1186/s12918-017-0518-x
call_split See protocol

[…] predict gene were linked to each other if the gene was a predicted target of the miRNAs distributed in human. The potential miRNA were connected with those related target which were obtained from the PharmGKB database [], and Therapeutic Targets Database (http://bidd.nus.edu.sg/group/bidd.htm).In pharmaceutical systems, network consists of nodes and edges (connections between nodes), that is a mat […]

library_books

Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide Induced Acute Kidney Injury via Anti inflammatory and Antioxidant Activities

2017
Front Pharmacol
PMCID: 5735979
PMID: 29311915
DOI: 10.3389/fphar.2017.00872

[…] and were placed into the Similarity ensemble approach (SEA) database (http://sea.bkslab.org/) for simulating molecular docking. The predicted targets were input to Therapeutic Target Database (TTD), PharmGKB, and Drugbank databases to identify their roles in inflammation and renal disease. […]

library_books

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database

2017
Clin Pharmacol Ther
PMCID: 5836850
PMID: 29134625
DOI: 10.1002/cpt.910

[…] forms, and Next‐Generation Sequencing. Examples include the Pharmacogenomic Clinical Annotation Tool (PharmCAT), which takes genomic data to make haplotype calls and get CPIC annotations (https://www.pharmgkb.org/page/pharmcat); Astrolabe, a tool developed to assign CYP2D6 genotype from Whole Genome Sequence data (currently expanded to CYPs 2C9 and 19); or tools that are integrated into commercial […]

Citations

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PharmGKB institution(s)
Department of Genetics, Stanford University, Palo Alto, CA, USA

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