A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype–phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Source text: Houle et al., 2010.
A tool that allows multi-locus and multi-level association analysis of genotypic and…
A tool that allows multi-locus and multi-level association analysis of genotypic and phenotypic data. APSampler was tested on a simulated data set and on a case-control MS (multiple sclerosis) study for ethnic Russians. For the simulated data, the…
A research programme set up to identify genes in the mouse, which if mutated (or…
A research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development…
Provides a comprehensive, curated, multidimensional database for developmental…
Provides a comprehensive, curated, multidimensional database for developmental phenotypes, cell-specific gene functions, differentiation trajectories and a multiscale model of lineage differentiation in the C. elegans embryo. Digital development…
Maintains and provides public archival, retrieval and analytical services for biological…
Maintains and provides public archival, retrieval and analytical services for biological information. The contents of the DDBJ databases are shared with the US National Center for Biotechnology Information (NCBI) and the European Bioinformatics…
A database of salt-tolerant plants-halophytes. Records of plant species tolerant of salt…
A database of salt-tolerant plants-halophytes. Records of plant species tolerant of salt concentrations of around 80 mM sodium chloride or more have been collected, along with data on plant type, life form, ecotypes, maximum salinity tolerated, the…
A leading international network infrastructure for archiving and worldwide provision of…
A leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface…
An online resource compiling data from high-throughput Drosophila in vivo and in vitro…
An online resource compiling data from high-throughput Drosophila in vivo and in vitro RNAi screens. FLIGHT includes details of RNAi reagents and their predicted off-target effects, alongside RNAi screen hits, scores and phenotypes, including images…
Serves a dual role, tracking both production of reagents for RNA interference (RNAi)…
Serves a dual role, tracking both production of reagents for RNA interference (RNAi) screening in Drosophila cells and RNAi screen results. FlyRNAi is used as a platform for community availability of protocols, tools, and other resources useful to…
Integrates diverse types of omics data across mammals to advance understanding of the…
Integrates diverse types of omics data across mammals to advance understanding of the genetic basis of gestation and pregnancy-associated phenotypes and to accelerate the translation of discoveries from model organisms to humans. GEneSTATION…
A database containing phenotypes from RNA interference (RNAi) screens in Drosophila and…
A database containing phenotypes from RNA interference (RNAi) screens in Drosophila and human. In addition, the database provides an updated resource of RNAi reagents and their predicted quality. RNAi screening data is extracted from the literature…
A multispecies integrative information system dedicated to plant and fungi pests. GnpIS…
A multispecies integrative information system dedicated to plant and fungi pests. GnpIS bridges genetic and genomic data, allowing researchers access to both genetic information (e.g. genetic maps, quantitative trait loci, markers, single nucleotide…
Makes available annotations of RNAi phenotypes, which were gathered in a large scale RNAi…
Makes available annotations of RNAi phenotypes, which were gathered in a large scale RNAi screen in the red flour beetle Tribolium castaneum (iBeetle screen). In addition, it provides access to sequence information and links for all Tribolium…
It is the European Research Infrastructure for phenotyping and archiving of model…
It is the European Research Infrastructure for phenotyping and archiving of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to…
Provides the biomedical community with a unified point of access to mutant mice and rich…
Provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for…
A database based on a functional ontology system that unambiguously centralize the…
A database based on a functional ontology system that unambiguously centralize the knowledge of limb regeneration experiments in a diverse set of model organisms, enabling the unambiguous description, centralize storage and manual and automated…
A collaborative standardized collection of measured data on laboratory mouse strains and…
A collaborative standardized collection of measured data on laboratory mouse strains and populations. MPD includes baseline phenotype data sets as well as studies of drug, diet, disease and aging effect. Also includes protocols, projects and…
Organizes information related to human medical genetics, such as attributes of conditions…
Organizes information related to human medical genetics, such as attributes of conditions with a genetic contribution. The core content of the record may include names, identifiers used by other databases, mode of inheritance, clinical features, and…
A comprehensive data collection for maize. Optimas-DW integrates data from different data…
A comprehensive data collection for maize. Optimas-DW integrates data from different data domains such as transcriptomics, metabolomics, ionomics, proteomics and phenomics. A web interface allows users to browse through all stored experiment data in…
Provides information on the phenotypic effects of 4865 human diseases, 1667 drugs and…
Provides information on the phenotypic effects of 4865 human diseases, 1667 drugs and 5361 genetically modified mouse models on 26 different organ systems. Disease symptoms, drug side effects and mouse phenotypes are mapped to the System Organ Class…
A multi-organism phenotype-genotype database including human, mouse, fruit fly, C.…
A multi-organism phenotype-genotype database including human, mouse, fruit fly, C. elegans, and other model organisms. The inclusion of gene indices (NCBI Gene) and orthologues (same gene in different organisms) from HomoloGene allows to compare…
An algorithm for the identification of pathways and networks associated with different…
An algorithm for the identification of pathways and networks associated with different phenotypes. PhenoNet uses two types of input data: gene expression data (RMA, RPKM, FPKM, etc.) and phenotypic information, and integrates these data with curated…
An automated method to provide evidence about gene-disease associations by analysing…
An automated method to provide evidence about gene-disease associations by analysing phenotype information. PhenoDigm integrates data from a variety of model organisms and, at the same time, uses several intermediate scoring methods to identify only…
Merges NHGRI genome-wide association study (GWAS) catalog data with several databases…
Merges NHGRI genome-wide association study (GWAS) catalog data with several databases housed at the National Center for Biotechnology Information (NCBI), including Gene, dbGaP, OMIM, GTEx and dbSNP. This phenotype-oriented resource, intended for…
A manually curated database and software tool for planarian regenerative experiments,…
A manually curated database and software tool for planarian regenerative experiments, based on a mathematical graph formalism. Planform contains more than a thousand experiments from the main publications in the planarian literature. The software…
An archive for collecting, managing and searching information of the T-DNA insertion…
An archive for collecting, managing and searching information of the T-DNA insertion mutants generated by an enhancer trap system. RMD can be searched by keywords, nucleotide sequence or protein sequence. This database provides three classes of…
An integrated phenotype database of Arabidopsis mutant traits using a controlled…
An integrated phenotype database of Arabidopsis mutant traits using a controlled vocabulary. RARGE integrates the phenotypes of four Arabidopsis mutant lines (including two loss-of-function and two gain-of-function lines) by mapping descriptions…
Contains a compendium of publicly available data and provides information on experimental…
Contains a compendium of publicly available data and provides information on experimental methods and phenotypic results, including raw data in the form of images and streaming time‐lapse movies. Phenotypic summaries together with graphical…
An online application for subgroup-free residue-level genotype-phenotype correlation. In…
An online application for subgroup-free residue-level genotype-phenotype correlation. In contrast to similar methods, SigniSite does not require any pre-definition of subgroups or binary classification. Input is a set of protein sequences where each…
A bioinformatics web app for identifying network-based biomarkers that most correlate…
A bioinformatics web app for identifying network-based biomarkers that most correlate with patient survival data. SurvNet is a valuable bioinformatic tool for identifying network-based biomarkers that most correlate with patient survival data.…
An information retrieval system designed to link plant genomic data in the context of…
An information retrieval system designed to link plant genomic data in the context of phenotypic attributes for a detailed forward genetic research. LAILAPS comprises around 65 million indexed documents, encompassing >13 major life science…
A tomato mutant database providing visible phenotypic data of tomato mutant lines…
A tomato mutant database providing visible phenotypic data of tomato mutant lines generated by ethylmethane sulfonate (EMS) treatment or gamma-ray irradiation in the genetic background of Micro-Tom, a small and rapidly growing variety. In the…
Aims to create a knockout allele in every protein coding gene in the zebrafish genome,…
Aims to create a knockout allele in every protein coding gene in the zebrafish genome, using a combination of whole exome enrichment and Illumina next generation sequencing. Each allele created is analysed for morphological differences and published…
The goal of this project is to use TILLING to generate and distribute loss-of-function…
The goal of this project is to use TILLING to generate and distribute loss-of-function mutations in genes of interest to the zebrafish community. The zebrafish TILLING project is a joint effort of the Moens lab at the Fred Hutchinson Cancer Research…
