Detects novel gene-disease associations in humans. PhenoPred is based on an experimental protein-protein interaction (PPI) network, protein-disease associations, as well as protein sequence and functional annotation. It prioritizes genes based on their likelihood to be associated with a given disease or can prioritize diseases for a given query gene. The tool organizes disease terms into a hierarchical structure expanding from the “disease” term to the most specific disease names in a top-down manner, by using Disease Ontology (DO) information.
School of Informatics, Indiana University, Bloomington, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
PhenoPred funding source(s)
Partially supported by the Indiana Genomics Initiative, by the Lilly Endowment, by DBI-0644017 grant, by K22LM009135 and P01AG018397.