A web-based resource to aid analysis of existing biological data and inspire future biological investigations. Phosphomouse presents experimental data about tissue-specific protein abundance and phosphorylation, including 12000 proteins and 36000 phosphorylation sites from 9 mouse tissues. These data revealed distinctive and complementary protein and phosphoprotein expression profiles that support each tissue’s unique physiology. Moreover, by combining protein abundance measurements with phosphorylation observations, we could distinguish tissue-specific phosphorylation of ubiquitous proteins from phosphorylation of tissue-specific proteins.
Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA
Phosphomouse funding source(s)
This work was funded in part by a grant from the NIH (HG3456) and by an industry-sponsored research project with ThermoFisher Scientific.