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- person_outline Jiang Qian
Publication for PhosphoNetworks
Integrating Phosphoproteomics and Bioinformatics to Study Brassinosteroid Regulated Phosphorylation Dynamics in Arabidopsis
[…] ciated with specific kinases by searching manually the literature and databases, including PhosPhAt (the Arabidopsis phosphorylation site database) , HPRD (Human Protein Reference Database) , and PhosphoNetworks . A motif-kinase association was constructed if the motif was identical to the recognizing pattern of a given kinase reported by literature or described in a database.To reveal the d […]
Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations
[…] 5 and cluster 6 members, indicating coordinated increase or decrease of phosphorylation at multiple sites within a protein.Given the central role of kinases in mediating Ras responses and modulating phosphonetworks, we examined their contribution to our data sets. In total, we detected peptides from 38 kinases ( Table 3). A total of 35 kinase phosphopeptides out of 96 were responsive (≥1.5-fold c […]
Integrating phosphoproteomics in systems biology
[…] ks. High-throughput technologies and computational approaches have been developed to identify these relevant kinase–substrate relationships, and the results are deposited into network databases, like phosphoNetworks and phosphoPOINT . PhosphoNetworks contains high-resolution phosphorylation networks derived from protein microarray and MS-based experiments, and it integrates a range of approaches t […]
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