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Protein phosphorylation catalyzed by kinases plays crucial regulatory roles in intracellular signal transduction. With the increasing number of experimental phosphorylation sites that has been identified by mass spectrometry-based proteomics, the desire to explore the networks of protein kinases and substrates is motivated.
(Lee et al., 2011) RegPhos: a system to explore the protein kinase-substrate phosphorylation network in humans. Nucleic Acids Res.