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PhyloWGS

A method that can be applied to WGS data from one or more tumor samples to reconstruct complete genotypes of these subpopulations based on variant allele frequencies (VAFs) of point mutations and population frequencies of structural variations. Unlike all previous methods, PhyloWGS appropriately corrects SSM population frequencies in regions overlapping CNVs and is fast enough to perform reconstruction of at least five cancerous subpopulations based on thousands of mutations.

PhyloWGS specifications

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Information

Unique identifier	OMICS_07695
Name	PhyloWGS
Software type	Package/Module
Interface	Command line interface
Restrictions to use	None
Operating system	Unix/Linux
Programming languages	C++, Python
Computer skills	Advanced
Stability	Stable
Maintained	Yes

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Documentation

Issues: https://github.com/morrislab/phylowgs/issues

Maintainer

Quaid Morris <>

Publication for PhyloWGS

PhyloWGS: reconstructing subclonal composition and evolution from whole-genome sequencing of tumors.

2015 Genome Biol

PMCID: 4359439

PMID: 25786235

DOI: 10.1186/s13059-015-0602-8

PhyloWGS institution(s)

Edward S Rogers Sr Department of Electrical and Computer Engineering, University of Toronto, Toronto, Canada

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