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PIDD specifications


Unique identifier OMICS_21433
Alternative name Protein Inter-Atomic Distance Distribution Database
Restrictions to use None
Database management system MySQL
Community driven No
Data access Browse
User data submission Not allowed
Maintained No


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Publication for Protein Inter-Atomic Distance Distribution Database

PIDD citations


Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models

PMCID: 5828188
PMID: 29535819
DOI: 10.18632/oncotarget.23623

[…] tory genes (CDKN1A, SFN, GADD45G, GADD45GIP1, G0S2, MAPK12, PTTG1, and BORA) and down-regulation of cell cycle-promoting genes (CCNE2, CCNG2, CCNK, TTK, and WEE1). Further, apoptosis-promoting genes (PIDD1, BIK, MAPK11, PANO1, NFKBID, and NFKBIE) were up-regulated while apoptosis-inhibiting genes (XAF1, CAAP1, and REL) were down-regulated in PL + GEM-treated tumors (Figure ).PL and GEM both induce […]


A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T‐cell dysfunction

PMCID: 5118205
PMID: 27896283
DOI: 10.1002/mgg3.237

[…] res were recalibrated and variant calling was performed using GATK. ANNOVAR (v2013August23)(Wang et al. ) was then used for variant annotation. Finally, HGMD annotations and additional information on PIDD candidate genes were added to ANNOVAR‐annotated files using an in‐house developed annotation pipeline.Exome sequencing of patients #3 and 4 was performed in Houston at the Human Genome Sequencing […]


Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

PLoS Genet
PMCID: 3744428
PMID: 23966881
DOI: 10.1371/journal.pgen.1003726

[…] nonical half-sites (single decamers) and three-quarter-sites, some of which were originally classified as biologically relevant response elements (REs) in, for example, the pro-apoptotic target genes PIDD and APAF1 . Moreover, REs in many other functionally important pro-apoptotic genes show on average less similarity to the p53 consensus sequence and a lower degree of evolutionary conservation as […]


Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

PMCID: 3365438
PMID: 22515271
DOI: 10.1042/BJ20111588

[…] sh in PBS. Bands were visualized and quantified using the Odyssey Infrared Imager (LI-COR Biosciences). Primary antibodies used were anti-(caspase 2) (custom-made []), anti-RAIDD (Stressgen) and anti-PIDD (Axxora). As a loading control the same membranes were incubated with antibodies against α-tubulin (1:10000; Abcam), ERK (extracellular-signal-regulated kinase) 1 (1:10000; Santa Cruz Biotechnolo […]


PIDDosome independent tumor suppression by Caspase 2

Cell Death Differ
PMCID: 3438502
PMID: 22595758
DOI: 10.1038/cdd.2012.54

[…] To monitor 53BP-1 and γH2AX foci, sorted immature and mature B cells from Eμ-Myc, Eμ-Myc/Pidd−/−and Eμ-Myc/Casp2−/− mice were stained as described elsewhere (Viale et al., 2009). Pictures were taken with a Leica SP5 confocal laser-scanning microscope (Vienna, Austria) equipped with a × 63 […]


CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5 Like Domain

PLoS One
PMCID: 3210808
PMID: 22087307
DOI: 10.1371/journal.pone.0027396

[…] idence prediction can be made for the region corresponding to the cytoplasmic portion of UNC5b, namely a ZU5 domain (as initially found in ZO-1 and UNC5), followed by a UPA domain (conserved in UNC5, PIDD and Ankirins) and by a Death Domain (DD) fold. Interestingly, the same domain organization is also present at the C-terminus of PIDD, a LRR containing protein controlling apoptosis and NF-κB acti […]


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PIDD institution(s)
Program on Bioinformatics and Computational Biology, Department of Biochemistry, Biophysics and Molecular Biology and Department of Mathematics, Iowa State University, Ames, IA, USA
PIDD funding source(s)
Partially supported by the research funds provided by the Department of Mathematics, the Graduate Program on Bioinformatics and Computational Biology, and the Lawrence Baker Center for Bioinformatics and Biological Statistics at Iowa State University.

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