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Many computational tools have been proposed during the two last decades for predicting piRNAs, which are molecules with important role in post-transcriptional gene regulation. However, these tools are mostly based on only one feature that is generally related to the sequence. Discoveries in the domain of piRNAs are still in their beginning stages, and recent publications have shown many new properties.
(Boucheham et al., 2017) IpiRId: Integrative approach for piRNA prediction using genomic and epigenomic data. PLoS One.