PK-Sim statistics

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PK-Sim specifications


Unique identifier OMICS_16054
Name PK-Sim
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Windows
Computer skills Medium
Stability Stable
Maintained Yes


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  • person_outline MoBi Team <>

Publication for PK-Sim

PK-Sim in publications

PMCID: 5827733
PMID: 29507756
DOI: 10.1038/s41540-018-0048-1

[…] signatures, or design metabolic intervention strategies leading to optimal risk-benefit ratios in patient care., the human pbpk models of isoniazid were built with the pbpk modeling software pk-sim® (version 7.1.0; bayer ag, 2017). model parameter identification was performed in matlab (version; the mathworks inc., natick, ma) and mobi®. the latest versions of pk-sim® […]

PMCID: 5845054
PMID: 29234936
DOI: 10.1007/s10928-017-9559-4

[…] in order to represent at whole body level the fundamental mechanisms driving the distribution and clearance of large molecules like therapeutic proteins. the model was built as an extension of the pk-sim model for small molecules incorporating (i) the two-pore formalism for drug extravasation from blood plasma to interstitial space, (ii) lymph flow, (iii) endosomal clearance and (iv) […]

PMCID: 5572381
PMID: 28571120
DOI: 10.1002/psp4.12205

[…] of test compounds. finally, the newly identified organ model structures and parameters were implemented in the commercial modeling platform pk‐sim and mobi (, in the first step, a systematic literature search was performed to identify the anatomic compartments of the testes and the thyroid gland that are most relevant for drug distribution […]

PMCID: 5524914
PMID: 28740200
DOI: 10.1038/s41598-017-04574-z

[…] that would have been impossible to achieve by conventional methods., pbpk models for the six cocktail drugs and their corresponding metabolites were developed by using the the free pbpk software pk-sim® and mobi v6.0.3 ( the parameters given in tables  and are sufficient to inform each specific pbpk model in this study and to perform […]

PMCID: 5564636
PMID: 28636998
DOI: 10.18632/oncotarget.18380

[…] model describes the pharmacokinetic parameters considering realistic human parameters, such as blood flow indifferent organs and the tissue/blood partition., all results were depicted using standard pk-sim and mobi graphical output. numerical evaluation and visual predictive checks were adapted for comparison of predicted and clinically observed results. the graphical representation […]

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PK-Sim institution(s)
Bayer AG, Drug Discovery, Pharmaceuticals, Clinical Pharmacometrics, Wuppertal, Germany

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