Consists of a singular value decompositions (SVD)-based pathways analysis method. PLAGE analyzes gene expression data in terms of a collection of predefined pathways and complexes. This approach quantifies the level of activity of each pathway within each sample and uses the activity levels as the basis for making comparisons. It can be useful for gene regulation, for clustering and classification, and for discovery of novel gene-pathway associations.
Department of Biostatistics and Bioinformatics and Center for Bioinformatics and Computational Biology, Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
PLAGE funding source(s)
Supported by the NIH through the Duke University Center for Translational Research (5 P30 AI051445-03) and of the NSF through a grant to David Bird (NCSU; DBI 0077503) as well as the Duke Center for Bioinformatics and Computational Biology.