Unlock your biological data

?

Polyadenylation site databases | RNA modification data analysis

Alternative polyadenylation (APA) is a widespread mechanism that contributes to the sophisticated dynamics of gene regulation. Approximately 50% of all protein-coding human genes harbor multiple polyadenylation (PA) sites; their selective and combinatorial use gives rise to transcript variants with differing length of their 3' untranslated region (3'UTR). Shortened variants escape UTR-mediated regulation by microRNAs (miRNAs), especially in cancer, where global 3'UTR shortening accelerates disease progression, dedifferentiation and proliferation.

Source text:
(Muller et al., 2014) APADB: a database for alternative polyadenylation and microRNA regulation events. Database (Oxford).

0 - 0 of 0 results
1 - 7 of 7 results
filter_list Filters
pets Taxonomy
import_contacts Journal
1 - 7 of 7 results