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PolyCTLDesigner

A program that is intended for constructing polyepitope immunogens. Given a set of either known or predicted T-cell epitopes the program selects N-terminal flanking sequences for each epitope to optimize its binding to TAP (if necessary) and joins resulting oligopeptides into a polyepitope in a way providing efficient liberation of potential epitopes by proteasomal and/or immunoproteasomal processing. And it also tries to minimize the number of non-target junctional epitopes resulting from artificial juxtaposition of target epitopes within the polyepitope. For constructing polyepitopes, PolyCTLDesigner utilizes known amino acid patterns of TAP-binding and proteasomal/immunoproteasomal cleavage specificity together with genetic algorithm and graph theory approaches.

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PolyCTLDesigner classification

PolyCTLDesigner specifications

Software type:
Package/Module
Restrictions to use:
None
Programming languages:
Python
Stability:
Stable
Interface:
Command line interface
Operating system:
Unix/Linux
Computer skills:
Advanced
Maintained:
Yes

PolyCTLDesigner distribution

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No versioning.

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Publications

Institution(s)

State Research Center of Virology and Biotechnology "Vector", Koltsovo, Novosibirsk Region, Russian

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