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PolyDoms specifications


Unique identifier OMICS_21442
Name PolyDoms
Restrictions to use None
Database management system Oracle
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • person_outline Bruce Aronow

Publication for PolyDoms

PolyDoms citations


Candidate gene association studies: a comprehensive guide to useful in silico tools

BMC Genet
PMCID: 3655892
PMID: 23656885
DOI: 10.1186/1471-2156-14-39

[…] otein structure models, also linking out to functional analysis of the SNP effect on protein. Data from various algorithms and functional criteria applied to the dbSNP dataset have been integrated by PolyDoms (http://polydoms.cchmc.org) [] to predict structural and functional protein variations, also integrating data on pathways, interactions and allelic variations from various sources []. UniProt […]


Chapter 15: Disease Gene Prioritization

PLoS Comput Biol
PMCID: 3635969
PMID: 23633938
DOI: 10.1371/journal.pcbi.1002902

[…] ay or may not be disease associated. In fact, most methods estimate that only 25–30% of the nsSNPs negatively affect protein function . Databases like OMIM , and more explicitly, SNPdbe , SNPeffect , PolyDoms , [email protected] Glance and DMDM map SNPs to known structural/functional effects and diseases. Computational tools that make predictions about functional and disease-associated effects of SNPs […]


Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque

Genome Biol
PMCID: 3218825
PMID: 21733155
DOI: 10.1186/gb-2011-12-7-r63

[…] sed to extract the corresponding nonsynonymous-SNP-containing druggable domains.To identify the human SNPs within the domains detected in macaque, we used 273 gene symbols as queries to search in the PolyDoms database, which integrates all coding SNPs in human protein domains. […]


MutDB: update on development of tools for the biochemical analysis of genetic variation

Nucleic Acids Res
PMCID: 2238958
PMID: 17827212
DOI: 10.1093/nar/gkm659

[…] aiming to understand the biochemical effects of nonsynonymous SNPs and disease-associated mutation have been developed. These include SIFT (), PolyPhen (), SNPs3D (), PANTHER (), PMUT (), LS-SNP (), PolyDoms () and SNPEffect (). These methods and their resulting datasets generally apply DNA and protein sequence, protein structure and/or evolutionary features to classify a query amino acid substit […]


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PolyDoms institution(s)
Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA
PolyDoms funding source(s)
Supported by grants NCI UO1 CA84291-07 (Mouse Models of Human Cancer Consortium), NIH R24 DK 064403 (Digestive Diseases Research Development Center—DDRDC), NIEHS ES-00-005 (Comparative Mouse Genome Centers Consortium) and NIEHS P30-ES06096 (Center for Environmental Genetics).

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