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PolymiRTS Database specifications

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Unique identifier OMICS_00391
Name PolymiRTS Database
Alternative name polymirts
Restrictions to use None
Maintained Yes

Publications for PolymiRTS Database

PolymiRTS Database citations

 (10)
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Genetic variation at the microRNA binding site of CAV1 gene is associated with lung cancer susceptibility

2017
Oncotarget
PMCID: 5696234
PMID: 29190968
DOI: 10.18632/oncotarget.21687
call_split See protocol

[…] In order to screen out those microRNAs that may binding to 3′UTR region of CAV1 mRNA around rs1049337, we adopted 4 database for microRNA predication, including MirSNP [], miRNASNP [], PolymiRTS Database 3.0 [], SNPinfo web server [].MicroRNA mimics were purchased from GenePharma (GenePharma, China). A 602-bp fragment of CAV1 3′UTR containing rs1049337-C or rs1049337-T were amplifie […]

library_books

Structure and functional impact of seed region variant in MIR 499 gene family in bronchial asthma

2017
PMCID: 5591547
PMID: 28886711
DOI: 10.1186/s12931-017-0648-0

[…] lap any regulatory region or motif features. However, being in the seed region at the 5′ end of miR-499a-3p generates the possibility of creating an altered target gene set for that particular. Using PolymiRTS Database 3.0 platform, identified the disruption of 667 (41.8%) genes of the miR-499a targets and creation of new 763 genes when A allele is substituted by G at the seed region sequence: AAC […]

library_books

The correlation between CRB1 variants and the clinical severity of Brazilian patients with different inherited retinal dystrophy phenotypes

2017
Sci Rep
PMCID: 5561187
PMID: 28819299
DOI: 10.1038/s41598-017-09035-1

[…] pendent Depletion (CADD) software was used to evaluate changes in non-coding regions of the CRB1 gene. The Human Splicing Finder was used to check possible aberrant splicing. The bioinformatics tools PolymiRTS Database 3.0 and TargetScan v.7.0 were used to evaluate changes in miRNAs or miRNA binding sites.For amino acid conservation analysis, CRB1 gene of 38 species was compared. A multiple sequen […]

library_books

Cis acting single nucleotide polymorphisms alter MicroRNA mediated regulation of human brain expressed transcripts

2016
Hum Mol Genet
PMCID: 5418741
PMID: 28171541
DOI: 10.1093/hmg/ddw317

[…] s of ‘seed-altering’ SNPs. However, because TargetScan is based upon MREs in the 3’UTR, and the model was trained with data from a single cell type, not all SNP-MRE interactions will be captured. The PolymiRTS () database identifies and annotates SNPs in MREs which have been biologically tested, but again focuses on miRNA binding regions in the 3’UTR. Finally, mrSNP () provides a web service for r […]

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MicroRNA related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer

2016
Oncotarget
PMCID: 5008387
PMID: 26988918
DOI: 10.18632/oncotarget.8134
call_split See protocol

[…] Candidate SNPs at miRNA-binding sites in the 3′-UTR of apoptotic pathway genes were selected using the PolymiRTS Database 3.0 (http://compbio.uthsc.edu/miRSNP/) and Ensemble Asia database (release 79, http://asia.ensembl.org/index.html?redirect = no). SNPs in the apoptotic pathway previously reported i […]

library_books

Genetic variants in microRNA genes: impact on microRNA expression, function, and disease

2015
Front Genet
PMCID: 4439572
PMID: 26052338
DOI: 10.3389/fgene.2015.00186

[…] f variants, needing only the genomic location and alternative allele of the variant.If a variant is located in a miRNA seed sequence, the effect on target binding can also be assessed in silico. Both PolymiRTS database () and miRNASNP () contain lists of predicted gain and loss of target binding sites for seed sequence variants that can be browsed. To assess the impact of variants in miRNA promote […]


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PolymiRTS Database institution(s)
Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA and Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN, USA

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