Implement a likelihood-based framework for calling single nucleotide variants and detecting de novo point mutation events in families for next-generation sequencing data. In addition to facilitating detection and genotyping of SNPs, Polymutt can interface with existing tools to improve the accuracy of more challenging short insertion deletion polymorphisms and other types of variants. Polymutt should make studies of families even more attractive because, in addition to making it easy to study rare variants and de novo mutation events, family studies will now be able to better transform sequence data into accurate genotypes.