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Pharmacometrics is a scientific discipline that integrates pharmacokinetics, pharmacodynamics, pharmacology, physiology, knowledge about diseases, and statistics to quantify interactions between drugs and patients using mathematical models (Lee et al., 2011; Barrett et al., 2008; van der Graaf, 2012). In recent decades, pharmacometric approaches, such as pharmacokinetic-pharmacodynamic modeling and simulation, are increasingly being applied in the drug development process.
(Lee et al., 2011) Impact of pharmacometric analyses on new drug approval and labelling decisions: a review of 198 submissions between 2000 and 2008. Clin Pharmacokinet.
(Barrett et al., 2008) Pharmacometrics: a multidisciplinary field to facilitate critical thinking in drug development and translational research settings. J Clin Pharmacol.
(van der Graaf, 2012) CPT: Pharmacometrics and Systems Pharmacology. CPT Pharmacometrics Syst Pharmacol.
(Lim et al., 2017) Phxnlme: An R package that facilitates pharmacometric workflow of Phoenix NLME analyses. Comput Methods Programs Biomed.