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Natural selection plays a crucial role in the evolution of species, where random mutations are undergoing positive, purifying or balancing selection (Hurst, 2009) for adaptation to the living environments including climate change, availability and stability of nutrients, introduction of novel disease agents, dispersed niche, etc.
(Hurst, 2009) Fundamental concepts in genetics: genetics and the understanding of selection. Nat Rev Genet.
(Li et al., 2014) dbPSHP: a database of recent positive selection across human populations. Nucleic acids research.