Potential vaccine candidate databases | Immunology system data analysis
Vaccination is one of the most significant inventions in modern medicine. It has been used to dramatically improve human health. However, our efforts to develop vaccines to protect against many diseases have not been successful. For example, the infectious diseases AIDS, tuberculosis and malaria are three of the top five threats to human health, but there is not an effective and safe vaccine available against any of these diseases. Vaccines can also be developed against many noninfectious diseases, including cancer, allergy and autoimmune diseases.
Provides Malarial Vaccine Candidates. MalVac is composed of detailed analysis of proteins of various plasmodium species. Those proteins play an important role as vaccine candidates. The database contains data about the probability for Plasmodium protein to be an adhesin (MAAP Score), the number of paralogs, orthologs, number of transmembrane helices, signal peptides, beta wraps and the topology of the concerned protein.
Stores the information of manually curated vaccine adjuvants and their applications in vaccine development, collected in the VIOLIN vaccine database. Vaxjo is a web-based comprehensive vaccine database and analysis system that targets for vaccine research. The database contains manually curated vaccine adjuvants that have been used in a wide array of vaccines for a large variety of infectious diseases, as well as diseases such as cancer and allergies. It also allows bioinformatics analysis and comparison of various vaccine adjuvants.
Assists researchers in designing and discovering suitable epitopes/antigens for cancer vaccine/immunotherapy. This workbench takes full advantage of genomic data generated from cancer cell lines over the years.
Offers immuno-informatics datasets with potential vaccine candidates to facilitate rapid vaccine development against Mycobacteria. MycobacRV provides comprehensive analysis data for 742 predicted and known adhesin and adhesin like proteins from 23 strains and species of Mycobacteria. It can be useful for future developments in developing new vaccines for mycobacterial infections in general and tuberculosis in particular.
Adjuvants play a vital role in immunization particularly in case of epitope-based vaccines. VaccineDA has been made available to the scientific community as a webserver in order to assist the experimentalists in designing better immunomodulatory oligodeoxynucleotide (IMODN) based adjuvants using sequence information of the oligonucleotides. The models used in prediction have been developed on experimentally validated IMODNs using different Datasets.
Curates, stores, analyses and integrates various vaccine-associated research data. VIOLIN is a web-based vaccine database and analysis system. It includes licensed vaccines, vaccines being tested in clinical trials and vaccines that have been studied in research and experimentally verified effective in at least one laboratory animal model and the data collected for each vaccine covers vaccine components, protection efficacy and host immune responses. VIOLIN also contains specific software programs such as several for vaccine literature mining and vaccine design.
Provides an integrated database of human leukocyte antigens (HLAs) supertype-specific epitopes. HLAsupE is an online resource of promiscuous T cell epitopes that is organized based on the HLA supertypes. Each of the supertype-specific peptides in this resource was annotated in terms of its cross-reactivity to HLA molecules within the same supertype. It can be used as a resource for the development of epitope-based vaccines and immunotherapies with broad coverage of human population.