Potential vaccine candidate databases | Immunology system data analysis

Curates, stores, analyses and integrates various vaccine-associated research data. VIOLIN is a web-based vaccine database and analysis system. It includes licensed vaccines, vaccines being tested in clinical trials and vaccines that have been studied in research and experimentally verified effective in at least one laboratory animal model and the data collected for each vaccine covers vaccine components, protection efficacy and host immune responses. VIOLIN also contains specific software programs such as several for vaccine literature mining and vaccine design.

A database that combines antigenic data of flaviviruses, specialized analysis tools, and workflows for automated complex analyses focusing on applications in immunology and vaccinology. FLAVIdB represents a new generation of databases in which data and tools are integrated into a data mining infrastructures specifically designed to aid rational vaccine design by discovery of vaccine targets.

Provides a web-based tool which gathers the sieve analyses of Human Immunodeficiency Virus (HIV-1) vaccine efficacy trials. SieveSifter presents analysis conducted on the HVTN 502/Step trial, the HVTN 503/Phambili trial, the MHRP/Thai Health Ministry RV144 trial, and the HVTN 505 trial. Moreover, the database allows-specific comparisons of sequences isolated from vaccine versus placebo recipients.

Adjuvants play a vital role in immunization particularly in case of epitope-based vaccines. VaccineDA has been made available to the scientific community as a webserver in order to assist the experimentalists in designing better immunomodulatory oligodeoxynucleotide (IMODN) based adjuvants using sequence information of the oligonucleotides. The models used in prediction have been developed on experimentally validated IMODNs using different Datasets.

In silico resources developed to facilitate scientific community fighting against deadly virus EBOLA. EbolaVCR enlists possible vaccine candidates, therapeutic siRNAs and other related resources. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generated all the possible overlapping 9mer peptides from the proteins of ebolaviruses. Thirdly, conserved peptides across all the five ebolaviruses (four human pathogenic species) with no identical sequence in the human proteome, based on 1000 Genomes project, were identified. Finally, we identified peptide or epitope-based vaccine candidates that could activate both the B- and T-cell arms of the immune system. In addition, we also identified efficacious siRNAs against the mRNA transcriptome (absent in human transcriptome) of all the five ebolaviruses.

Provides Malarial Vaccine Candidates. MalVac is composed of detailed analysis of proteins of various plasmodium species. Those proteins play an important role as vaccine candidates. The database contains data about the probability for Plasmodium protein to be an adhesin (MAAP Score), the number of paralogs, orthologs, number of transmembrane helices, signal peptides, beta wraps and the topology of the concerned protein.

Includes information for a large set of vaccine vectors, vaccines using these vectors, and protective antigens used in these recombinant vector vaccines. The Vaxvec interface offers users three types of query: (1) query for vaccine vectors, (2) query for recombinant vector vaccines, and (3) query for protective antigens used in the recombinant vector vaccines. A vaccine vector page includes links to all vaccines that use the vector.

Allows a large-scale analysis on a large collection of annotated influenza sequences. FluKB is a knowledge-based system that integrates multiple types of influenza data and analytical tools into workflows to support vaccine target discovery. The database contains standardized data, integrating information on antigen sequences, and immunological epitopes. The set of integrated analysis tools and workflows are designed to aid rational vaccine design that integrates the content and the analytical tools in a unified system that enables the automation of complex queries and discovery.

Provides an integrated database of human leukocyte antigens (HLAs) supertype-specific epitopes. HLAsupE is an online resource of promiscuous T cell epitopes that is organized based on the HLA supertypes. Each of the supertype-specific peptides in this resource was annotated in terms of its cross-reactivity to HLA molecules within the same supertype. It can be used as a resource for the development of epitope-based vaccines and immunotherapies with broad coverage of human population.

Gathers DNA vaccines, plasmids, and protective antigens information. DNAVaxDB includes about 400 DNA vaccines,130 DNA vaccine plasmids and protective antigens specifically used in DNA vaccine development. The database allows users to make separated or linked query between the three categories. It also contains a search program which has been developed to support sequence similarity search on the database’s BLAST library, an exchange and a submission interface.

Serves as a web-based central repository of vaccine animal-response data. Vaxar is a one-stop resource for vaccine animal responses that combines online data curation, storage, and review with public data query and analysis. This resource contains data for over 160 pathogens and diseases, 30 animal host species, 3200 vaccines, and 1300 experimental studies of animal responses to these vaccines.

Stores the information of manually curated vaccine adjuvants and their applications in vaccine development, collected in the VIOLIN vaccine database. Vaxjo is a web-based comprehensive vaccine database and analysis system that targets for vaccine research. The database contains manually curated vaccine adjuvants that have been used in a wide array of vaccines for a large variety of infectious diseases, as well as diseases such as cancer and allergies. It also allows bioinformatics analysis and comparison of various vaccine adjuvants.

Offers immuno-informatics datasets with potential vaccine candidates to facilitate rapid vaccine development against Mycobacteria. MycobacRV provides comprehensive analysis data for 742 predicted and known adhesin and adhesin like proteins from 23 strains and species of Mycobacteria. It can be useful for future developments in developing new vaccines for mycobacterial infections in general and tuberculosis in particular.

Assists researchers in designing and discovering suitable epitopes/antigens for cancer vaccine/immunotherapy. This workbench takes full advantage of genomic data generated from cancer cell lines over the years.

Provides access to scientific and clinical information related to the use of keyhole limpet hemocyanin (KLH). KLH Site is a database that includes links to biomedical literature, breaking news of new vaccine development, and information on KLH biochemistry and use.