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Citations per year

Number of citations per year for the bioinformatics software tool PPCheck

Tool usage distribution map

This map represents all the scientific publications referring to PPCheck per scientific context
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PPCheck specifications


Unique identifier OMICS_20566
Name PPCheck
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Ramanathan Sowdhamini

Publication for PPCheck

PPCheck citations


Bioinformatics comparisons of RNA binding proteins of pathogenic and non pathogenic Escherichia coli strains reveal novel virulence factors

BMC Genomics
PMCID: 5571608
PMID: 28836963
DOI: 10.1186/s12864-017-4045-3

[…] active and the inactive hexamers of the protein for performing MD simulations, to save computational time. Various energy components of the dimer interface were measured using the in-house algorithm, PPCheck []. This algorithm identifies interface residues in protein-protein interactions on the basis of simple distance criteria, following which the strength of interactions at the interface are qua […]


Protein protein interfaces are vdW dominant with selective H bonds and (or) electrostatics towards broad functional specificity

PMCID: 5512853
PMID: 28729757
DOI: 10.6026/97320630013164

[…] anually curated non-redundant dataset of 278 heterodimer subunit interfaces as described elsewhere [] to relate interface size with vdW, H-bond and electrostatic energy to gain further insights using PPCheck (a robust tool for inter-atomic interface analysis) [, ]. This analysis is restricted to hetero complexes for the purpose of clarity and comparison with previously known information. It should […]


Integrative modelling of TIR domain containing adaptor molecule inducing interferon β (TRIF) provides insights into its autoinhibited state

Biol Direct
PMCID: 5397763
PMID: 28427457
DOI: 10.1186/s13062-017-0179-0
call_split See protocol

[…] domain to guide the docking, the top poses were those in which the BB loop was present in the interface Docked poses were ranked using DockScore [] and interactions at the interface identified using PPCheck []. Both these softwares were developed in the lab. DockScore is a scoring scheme that utilizes various parameters such as the number of interfacial hydrophobic residues, spatial clustering of […]


PIMA: Protein Protein interactions in Macromolecular Assembly a web server for its Analysis and Visualization

PMCID: 4857458
PMID: 27212837
DOI: 10.6026/97320630012009
call_split See protocol

[…] PPCheck (a tool for quantifying protein-protein interactions) was used to identify interactions in macro-molecular assemblies. Residues within a Calpha - Calpha distance threshold of 10Å are initially […]


Energetic Calculations to Decipher pH Dependent Oligomerization and Domain Swapping of Proteins

PLoS One
PMCID: 4456399
PMID: 26043007
DOI: 10.1371/journal.pone.0127716

[…] int near pH 10. At D-pH, the net charge on these basic amino acids is close to zero leading to weak salt bridge interactions at D-pH (). pH-dependent energy profile of NSI and detailed analysis using PPCheck server [] revealed unfavourable interactions between eight positively charged residues (). The magnitude of these unfavourable interactions drastically reduces at D-pH around 10, since net cha […]

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PPCheck institution(s)
National Centre for Biological Sciences, Bangalore, Karnataka, India; SASTRA University, Tirumalaisamudram, Thanjavur, Tamil Nadu, India
PPCheck funding source(s)
Supported by DBT-CoE grant (grant number: BT/01/COE/09/01).

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