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PPISURV specifications

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Unique identifier OMICS_12519
Name PPISURV
Interface Web user interface
Restrictions to use None
Input data PPISURV accepts as input a wide spectrum of gene identifiers (Entrez Gene Id, GeneSymbol, UniProt/Swiss-Prot, UniGene, Ensembl, RefSeqIDs).
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Alexey V. Antonov <>

Publication for PPISURV

PPISURV citations

 (8)
library_books

SPIN1, negatively regulated by miR 148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer

2018
PMCID: 5944004
PMID: 29743122
DOI: 10.1186/s13046-018-0748-9

[…] and classified as non-responders [] displayed marginally higher spin1 expression than those classified as responders (fig. , p = 0.0655). the prognostic role of spin1 was determined by the ppisurv (http://www.chemoprofiling.org/cgi-bin/geo/cancertarget/web_run_ct.v0.s1.pl) database [, ]. the results showed that patients with high expression of spin1 (n = 230) had poorer survival […]

library_books

Spleen Tyrosine Kinase Inhibition Modulates p53 Activity

2017
PMCID: 5726622
PMID: 29249894
DOI: 10.1177/1179066017731564

[…]  minutes at 37°c in the dark. in total, 10 000 events were recorded for each sample using the becton dickinson facscanto ii and facsdiva 6.0 software (becton dickinson) for acquisition and analysis., ppisurv was used to correlate survival rates in patients with cancer to the expression level of syk. in each data set, samples were grouped with respect to expression rank of the gene, which reflects […]

library_books

The neurotrophin Neuritin1 (cpg15) is involved in melanoma migration, attachment independent growth, and vascular mimicry

2016
PMCID: 5352040
PMID: 27901477
DOI: 10.18632/oncotarget.13585

[…] patient identity and data privacy was protected. furthermore, we used several sera from the study performed by raja et al. 2007 []., we used a free online datamining tool (http://www.bioprofiling.de/ppisurv). ppisurv automatically correlates expression of an input gene interactome with survival rates on > 40 publicly available clinical expression data sets covering various tumors involving […]

library_books

The cytoskeleton adaptor protein ankyrin 1 is upregulated by p53 following DNA damage and alters cell migration

2016
PMCID: 4855670
PMID: 27054339
DOI: 10.1038/cddis.2016.91

[…] of translational relevance of ank1 have been performed with the bioprofiling.de online datamining tools using publically available clinical gene expression data from the geo omnibus repository. the ppisurv tool was used to correlate gene expression data with cancer patient survival. to demonstrate translational relevance of potential association between ank1 and dna damage genes we used […]

library_books

Reconstruction of temporal activity of microRNAs from gene expression data in breast cancer cell line

2015
PMCID: 4712512
PMID: 26763900
DOI: 10.1186/s12864-015-2260-3

[…] the cytoscape software tool []. all statistical calculations, nca and clustering were done in matlab, mathworks., we conducted survival analysis of mirnas and tfs using the tools ‘mirumir’ [] and ‘ppisurv’ [] respectively, both developed by antonov av et al. these tools integrate publicly available clinical data such as the geo repository. briefly, these tools utilize the rank information […]

library_books

Characterization of novel markers of senescence and their prognostic potential in cancer

2014
PMCID: 4260747
PMID: 25412306
DOI: 10.1038/cddis.2014.489

[…] be used clinically to detect the presence of senescent cells in tissues and thus provide diagnostic and/or prognostic information for diseases such as cancer. to confirm this hypothesis, we used ppisurv, a novel online tool that correlates gene expression with survival rates in cancer patients using publicly available data. as shown in , high expression of our validated markers correlated […]


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PPISURV institution(s)
Toxicology Unit, Hodgkin Building, Medical Research Council, Leicester University, Leicester, UK; Molecular Pharmacology Laboratory, Technological University, St-Petersburg, Russia; Institute for Molecular Medicine Finland FIMM, University of Helsinki; Helsinki, Finland; Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Experimental Medicine and Surgery, University of Rome ‘Tor Vergata’, Rome, Italy; Department of Biochemistry, University of Leicester, Leicester, UK; Gene Expression Programme, Institute of Cytology, St-Petersburg, Russia
PPISURV funding source(s)
This work was supported by the UK Medical Research Council (MRC) and funding from Russian Federal grants 14.B37.21.1967, 16.740.11.036 and 11.G34.31.0069.

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