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PPSP specifications


Unique identifier OMICS_05931
Alternative name Prediction of PK-specific Phosphorylation site
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for Prediction of PK-specific Phosphorylation site

PPSP citations


Cysteine linked dimerization of BST 2 confers anoikis resistance to breast cancer cells by negating proapoptotic activities to promote tumor cell survival and growth

PMCID: 5386562
PMID: 28300825
DOI: 10.1038/cddis.2017.68

[…] that become phosphorylated upon virus-mediated BST-2 activation. Possibly, these or other tyrosines present in the different domains of BST-2 are phosphorylated. Indeed, in silico analysis using the PPSP software (http://ppsp.biocuckoo.org/) revealed that BST-2 contains four phosphorylatable tyrosines at positions 6, 8, 153 and 154. Aside from tyrosines, the cytoplasmic tail of BST-2 contains pho […]


Prediction of post translational modification sites using multiple kernel support vector machine

PMCID: 5410141
PMID: 28462053
DOI: 10.7717/peerj.3261

[…] ative analysis was based on ten-fold cross-validation process using collected datasets from several comprehensive sources. We compared the proposed method with existing PTM prediction methods such as PPSP (), GPS 3.0 (), and NetPhos () etc. The experimental results revealed that the proposed method achieved comparable or better performance than these state-of-the-art PTM sites prediction methods […]


Regulation of divalent metal transporter 1 by serine phosphorylation

PMCID: 5103878
PMID: 27681840
DOI: 10.1042/BCJ20160674

[…] nctional effects of this modification. Our observation is the first report of DMT1 (Nramp2) phosphorylation. Computer-based programs, such as KinasePhos [], GPS (group-based prediction system) [] and PPSP (prediction of PK-specific phosphorylation site) [], all indicate that the Ser43 in DMT1 is a potential site for protein kinase A/G/C family members as well as CK-2. Further research is necessary […]


Regulation of BLM Nucleolar Localization

PMCID: 5042399
PMID: 27657136
DOI: 10.3390/genes7090069

[…] re normalized by aligned length. Residues were colored by identity and property. BLM amino acids 1332 to 1349 were analyzed with the following programs: KinasePhos2.0 [], NetPhorest [], ScanSite3 [], PPSP [], Phosphonet [available online], and SABLE for Relative Solvent Accessibility (RSA) []. […]


PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

Nat Commun
PMCID: 4976202
PMID: 27485204
DOI: 10.1038/ncomms12431

[…] Stat3 and c-Src, respectively (). Immunoblotting analyses showed that only inhibition of c-Src abrogated EGF-induced the binding of Cdc25A to PKM2 (). Analysis of the Cdc25A amino acid sequence using PPSP (http://ppsp.biocuckoo.org) and DISPHOS (http://www.dabi.temple.edu) revealed that Y59, Y486 and Y518 are potential Tyr residues that can be phosphorylated by c-Src. An in vitro protein kinase as […]


PredPhos: an ensemble framework for structure based prediction of phosphorylation sites

PMCID: 4943517
PMID: 27437197
DOI: 10.1186/s40709-016-0042-y

[…] In this section, the proposed method (PredPhos) was benchmarked against PPSP, NetPhosK 1.0, KinasePhos 1.0 and GPS 2.1, four widely used kinase-specific predictors on the independent dataset with 171, 136, 43, 274 and 149 phosphorylation sites of family of PKA, PKC, CK2, […]


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PPSP institution(s)
School of Life Science, University of Science and Technology of China, Hefei, Anhui, China

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