PreADMET protocols

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PreADMET specifications

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Unique identifier OMICS_16048
Name PreADMET
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Unix/Linux
Programming languages C, PHP
Computer skills Medium
Version 2.0
Stability Stable
Maintained Yes

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  • person_outline Sungbo Hwang <>

PreADMET in pipelines

 (3)
2017
PMCID: 5343802
PMID: 28146074
DOI: 10.3390/ijms18020266

[…] compounds of lcbe, a computational simulation study was performed. for toxic risk prediction, four online computer programs: acd/labs (toronto, on, canada), admetsar server, pkcsm platform, and the preadmet web-based application (http://preadmet.bmdrc.kr/) were employed. the toxic risks assessed were interpreted and expressed in a flexible manner: (+) low potential, (++) medium risk, (+++) high […]

2017
PMCID: 5381078
PMID: 28376844
DOI: 10.1186/s40199-017-0174-0

[…] the current study, we evaluated in-vitro and in-silico profile of carboxylate derivatives of tributyltin (iv) complexes., admet and drug-likeliness properties were predicted using metaprint2d react, preadmet, swissadme and molsoft tools. swisstargetprediction predicted molecular targets for compounds. in-vitro bioactivity was evaluated by quantifying cytotoxicity against hepg2, thp-1 cell lines, […]

2017
PMCID: 5381078
PMID: 28376844
DOI: 10.1186/s40199-017-0174-0

[…] it also classified compounds as targets of p-glycoprotein (p-gp) efflux, inhibitors of cytochrome p450 enzymes cyp2c9, cyp2c19, cyp2d6 and cyp3a4 and substrates for metabolism by cyp2d6 and cyp3a4. preadmet anticipated toxicity of compound on models of ames test with or without metabolic activation by s9 (rat liver homogenate) against strains of salmonella typhimurium ta100 and ta1535 […]

PreADMET in publications

 (18)
PMCID: 5936909
PMID: 29765644
DOI: 10.1098/rsos.171750

[…] the drug-like and lead-like property analysis for the compounds generated a score of 0.25 which gave support to the positive results obtained in rule of five. adme properties were predicted using preadmet software [] in order to check their potential as anti-tubercular compounds. table 5.acomputed using screening assistant 2 program. pdl, progressive drug like; pll, progressive lead […]

PMCID: 5795847
PMID: 29391000
DOI: 10.1186/s12906-018-2116-x

[…] the physicochemical properties were calculated using marvinsketch 15.6.29 and gaussian 09 software package. the pharmacokinetic and toxicological properties were calculated on online server preadmet. further, the molecular docking study was conducted on autodock vina in pyrx 0.8., the aqueous solubility increased with increasing ph due to the ionization of ba leading to decrease […]

PMCID: 5683055
PMID: 29052076
DOI: 10.1007/s12017-017-8469-3

[…] of stat3. furthermore, we carried out an in silico toxicology and adme (absorption, distribution, metabolism, and extraction) evaluation previously by using computational adme qsar models, preadmet (http://preadmet.bmdrc.org) and stardrop (http://www.optibrium.com/stardrop/stardrop-features.php), to predicted the adme of mmpp (son et al. ). blood–brain barrier (bbb) penetration […]

PMCID: 5651222
PMID: 29081608
DOI: 10.6026/97320630013293

[…] is over 5 d) there are more than 10 h-bond acceptors [expressed as the sum of ns and os) e) compound classes that are substrates for biological transporters are exceptions to the rule., using preadmet online server (http://preadmet.bmdrc.org) the pharmacokinetics parameters like adsorption, distribution, metabolism, excretion and toxicology (adme/t) was calculated. this aspect calculates […]

PMCID: 5591938
PMID: 28932239
DOI: 10.1155/2017/5124165

[…] were analyzed for drug-relevant properties based on “lipinski's rule of five” and bioactivity prediction using the molinspiration web server []. further adme prediction was also conducted using the preadmet web server (http://preadmet.bmdrc.kr) [], where the risk of toxicity upon consumption of compounds can be predicted. four adme properties of g. bicolor bioactive compounds were tested: […]

PreADMET institution(s)
BMDRC, Yonsei Engineering rsearch complex, Yonsei University, Seodaemun-Gu, Seoul, Korea

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