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Protocols

PreADMET specifications

Information


Unique identifier OMICS_16048
Name PreADMET
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Unix/Linux
Programming languages C, PHP
Computer skills Medium
Version 2.0
Stability Stable
Maintained Yes

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No version available

Maintainer


  • person_outline Sungbo Hwang

PreADMET citations

 (18)
library_books

Identification of potent chromone embedded [1,2,3] triazoles as novel anti tubercular agents

2018
R Soc Open Sci
PMCID: 5936909
PMID: 29765644
DOI: 10.1098/rsos.171750

[…] the drug-like and lead-like property analysis for the compounds generated a score of 0.25 which gave support to the positive results obtained in rule of five. adme properties were predicted using preadmet software [] in order to check their potential as anti-tubercular compounds. table 5.acomputed using screening assistant 2 program. pdl, progressive drug like; pll, progressive lead […]

library_books

Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2)

2018
BMC Complement Altern Med
PMCID: 5795847
PMID: 29391000
DOI: 10.1186/s12906-018-2116-x

[…] the physicochemical properties were calculated using marvinsketch 15.6.29 and gaussian 09 software package. the pharmacokinetic and toxicological properties were calculated on online server preadmet. further, the molecular docking study was conducted on autodock vina in pyrx 0.8., the aqueous solubility increased with increasing ph due to the ionization of ba leading to decrease […]

library_books

(E) 2 Methoxy 4 (3 (4 methoxyphenyl) prop 1 en 1 yl) Phenol Ameliorates LPS Mediated Memory Impairment by Inhibition of STAT3 Pathway

2017
PMCID: 5683055
PMID: 29052076
DOI: 10.1007/s12017-017-8469-3

[…] of stat3. furthermore, we carried out an in silico toxicology and adme (absorption, distribution, metabolism, and extraction) evaluation previously by using computational adme qsar models, preadmet (http://preadmet.bmdrc.org) and stardrop (http://www.optibrium.com/stardrop/stardrop-features.php), to predicted the adme of mmpp (son et al. ). blood–brain barrier (bbb) penetration […]

library_books

Molecular docking analysis of aplysin analogs targeting survivin protein

2017
Bioinformation
PMCID: 5651222
PMID: 29081608
DOI: 10.6026/97320630013293

[…] is over 5 d) there are more than 10 h-bond acceptors [expressed as the sum of ns and os) e) compound classes that are substrates for biological transporters are exceptions to the rule., using preadmet online server (http://preadmet.bmdrc.org) the pharmacokinetics parameters like adsorption, distribution, metabolism, excretion and toxicology (adme/t) was calculated. this aspect calculates […]

library_books

Computational Analysis of Gynura bicolor Bioactive Compounds as Dipeptidyl Peptidase IV Inhibitor

2017
Adv Bioinformatics
PMCID: 5591938
PMID: 28932239
DOI: 10.1155/2017/5124165

[…] were analyzed for drug-relevant properties based on “lipinski's rule of five” and bioactivity prediction using the molinspiration web server []. further adme prediction was also conducted using the preadmet web server (http://preadmet.bmdrc.kr) [], where the risk of toxicity upon consumption of compounds can be predicted. four adme properties of g. bicolor bioactive compounds were tested: […]

library_books

KRICT 9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models

2017
Oncotarget
PMCID: 5620285
PMID: 28978145
DOI: 10.18632/oncotarget.19818

[…] and plasma protein binding highlight krict-9 as a viable drug. indeed, krict-9 is negative for all predicted toxicities evaluated by computational adme qsar models using preapmet (http://preadmet.bmdrc.org) and stardrop (http://www.optibrium.com). thus, our results here warrant running clinical trials to test krict-9 as a therapeutic agent to treat patients with ad., […]


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PreADMET institution(s)
BMDRC, Yonsei Engineering rsearch complex, Yonsei University, Seodaemun-Gu, Seoul, Korea

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