Predicts interface residues using local surface structural similarity. PrISe represents a local surface structure using structural elements. A structural element represents the surface of a central residue and its surrounding residues on the protein structure. PrISe decomposes the surface of a query protein in as many structural elements in the surface of the protein and search for similar elements in a data base containing all the structural elements in PDB. The central residue in each element in the database has been label as interface or non-interface. These labels are used to predict whether the central residue of each structural element in the query protein is or not an interface residue.