Corrects errors in high throughput DNA sequencing data. PREMIER’s approach consists in a hidden Markov model for the DNA sequencer outputs. This software applies error correction in a given read for both the forward and the backward directions. This method intends to enhance the correction of nucleotides in the beginning of the read and includes the prior belief on a nucleotide position returned by the Baum-Welch algorithm into the error correction steps.
Department of Statistics, Iowa State University, Ames, IA, USA; Department of Electrical & Computer Eng. Iowa State University, Ames, IA, USA; Department of Genetics, Development & Cell Biology Iowa State University, Ames, IA, USA
PREMIER funding source(s)
Supported by in part by NSF awards DMS-1120597 and CCF-1149860.