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Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It is essential for the proper cellular activity of numerous proteins, including Ras family GTPases and heterotrimeric G-proteins.
(Palsuledesai and Distefano, 2015) Protein prenylation: enzymes, therapeutics, and biotechnology applications. ACS Chem Biol.