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PrePPI specifications


Unique identifier OMICS_02966
Name PrePPI
Restrictions to use None
Maintained Yes


  • Plants and Fungi
    • Saccharomyces cerevisiae
  • Primates
    • Homo sapiens


  • person_outline Qiangfeng Cliff Zhang

Publication for PrePPI

PrePPI citations


Study on molecular mechanism of ANOS1 promoting development of colorectal cancer

PLoS One
PMCID: 5576693
PMID: 28854193
DOI: 10.1371/journal.pone.0182964

[…] ANOS1 has a higher correlation with CTHRC1 in Wnt signaling pathway ().Because only a few proteins interact with CTHRC1 and ANOS1, the proteins interacting with ANOS1 and CTHRC1 were predicted using PrePPI tool. The predicted results showed that The target protein YWHAE was the only protein that was common to both ANOS1 and CTHRC1 as it showed interactions with both the genes. Therefore, ANOS1 wa […]


Staphylococcus aureus Esx Factors Control Human Dendritic Cell Functions Conditioning Th1/Th17 Response

PMCID: 5519619
PMID: 28785545
DOI: 10.3389/fcimb.2017.00330

[…] ata (Holm and Rosenstrom, ). Among all structural homologs, only human proteins have been further analyzed.Human interactors of the proteins selected by the Dali server have been identified using the PrePPI server ( PrePPI combines the prediction of protein-protein interactions (PPI) with those coming from experimental evidence (Zhang et al., ). Predicted int […]


Bioinformatics analysis of the proteins interacting with LASP 1 and their association with HBV related hepatocellular carcinoma

Sci Rep
PMCID: 5339786
PMID: 28266596
DOI: 10.1038/srep44017

[…] teract with LASP-1, the information of target human proteins was retrieved from different public databases, including IntAct, BioGRID, APID, PINA2.0, Mentha, HitPredict, WiKi-Pi, PIPs, PPI-finder and PrePPI or from the studies reported in PubMed. A total of 390 predicted or experimentally validated LASP-1 interacting proteins were obtained. Given that predicated LASP-1 interactions in many databas […]


Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis

PMCID: 5312388
PMID: 27533088
DOI: 10.18632/oncotarget.11254

[…] The protein-protein interaction (PPI) network was conducted based on the identified proteins, and biological evidence was collected from PrePPI []. And then, network associated proteins were classified into 10 groups according to the GO (Gene Ontology) Annotation clustering. The network group analysis was conducted via DAVID database a […]


MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis

PMCID: 5312364
PMID: 27509054
DOI: 10.18632/oncotarget.11046

[…] To build the protein-protein interaction (PPI) network based on the significantly differentially expressed proteins finding in the MALDI-MS, we collected biological evidence from PrePPI []. After that, network related proteins were assigned to 10 functional synaptic protein groups by Gene Ontology (GO) Annotation clustering, which was performed using DAVID database (http://dav […]


A computational interactome and functional annotation for the human proteome

PMCID: 5115866
PMID: 27770567
DOI: 10.7554/eLife.18715.074

[…] templates (as determined from either the Gopher, OMA or KEGG databases). There is a wide range of LRs, either based on structural modeling alone (), or considering all sources of information used in PrePPI (). The wide range of LRs obtained from structural modeling demonstrates the sensitivity of our scoring function while the even wider range for the total PrePPI LR shows that other sources of e […]


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PrePPI institution(s)
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Columbia Initiative in Systems Biology, Columbia University, New York, NY, USA

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