- Unique identifier:
- Software type:
- Restrictions to use:
- Academic or non-commercial use
- Output data:
- The main output of PAINTOR is a probability for each variant to be causal that can be used for selection of SNPs to be tested for biological causality in functional assays.
- Computer skills:
- Source code URL:
- Probabilistic Annotation INtegraTOR
- Command line interface
- Input data:
- PAINTOR takes as input the following data for each set of SNPs at a locus: (i) summary association statistics (Z-scores); linkage disequilibrium matrix/matrices (pairwise Pearson correlations coefficients between each SNP) and (iii) functional annotation matrix (binary indicator of annotation membership).
- Operating system:
- Eigen, Nlopt
- Bogdan Pasaniuc <>
No open topic.
(Kichaev and Pasaniuc, 2015)
Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies.
Am J Hum Genet.
PMID: 26189819 DOI: 10.1016/j.ajhg.2015.06.007
(Kichaev et al., 2014)
Integrating functional data to prioritize causal variants in statistical fine-mapping studies.
PMID: 25357204 DOI: 10.1371/journal.pgen.1004722
Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
This research was supported by NIH grants R01-HG006399, R01-GM53275, and R21-CA182821.
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