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ProfileChaser specifications

Information


Unique identifier OMICS_04085
Name ProfileChaser
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability No
Maintained No

Publication for ProfileChaser

ProfileChaser citations

 (5)
library_books

The Effect of Statins on Blood Gene Expression in COPD

2015
PLoS One
PMCID: 4604084
PMID: 26462087
DOI: 10.1371/journal.pone.0140022

[…] different diseases, drugs, or perturbations. Concordant expression profiles leads to novel insights into the molecular mechanisms underlying a disease/drug of interest and generates hypotheses. Using ProfileChaser to find correlated profiles, a number of diseases were identified as having an expression profile that is similar to the statin use signature. The strongest correlation was with a Huntin […]

library_books

Database of Gene Co Regulation (dGCR): A Web Tool for Analysing Patterns of Gene Co regulation across Publicly Available Expression Data

2015
J Genomics
PMCID: 4303599
PMID: 25628763
DOI: 10.7150/jgen.10888

[…] has been successfully applied in the area of drug repositioning with the connectivity map (CMAP) initiative , and has led to the development of transcription based search engines such as GEM-TREND , ProfileChaser , Gene Expression Atlas and SPIED , , that have thrown up intriguing connections between diverse biological systems. These methodologies are not driven by gene discovery and the pinpoin […]

library_books

REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

2014
PMCID: 4309667
PMID: 25504525
DOI: 10.15252/emmm.201404601

[…] Glucocorticoids can induce catabolic/atrophic changes in multiple tissues including muscle, subcutaneous fat, and bone (Wang et al, ; Shimizu et al, ). We used ProfileChaser software to compare transcriptional responses to glucocorticoids in epidermis and other tissues, using our array data and DNA arrays deposited to NCBI (http://profilechaser.stanford.edu, […]

library_books

SPIEDw: a searchable platform independent expression database web tool

2013
BMC Genomics
PMCID: 4046673
PMID: 24199845
DOI: 10.1186/1471-2164-14-765

[…] ines with the objective of mapping drug to disease through direct expression profile correlation []. This methodology has been extended to collections of published expression studies in GEM-TREND [], ProfileChaser [], Gene Expression Atlas [] and SPIED []. The motivation behind SPIED was in the first place to define expression changes as relative to the average across the experimental series and t […]

library_books

Transcriptional data: a new gateway to drug repositioning?

2013
Drug Discov Today
PMCID: 3625109
PMID: 22897878
DOI: 10.1016/j.drudis.2012.07.014

[…] afe’ compounds never linked before to that MoA.Several tools are freely available for mining gene expression data repositories based on similarity with an input signature in a similar manner to cMap. ProfileChaser searches microarray repositories based on genome-wide patterns of differential expression, and MARQ mines GEO for experiments that generate a differential expression profile that is si […]

Citations

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ProfileChaser institution(s)
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

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