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Publication for ProfileChaser
The Effect of Statins on Blood Gene Expression in COPD
[…] different diseases, drugs, or perturbations. Concordant expression profiles leads to novel insights into the molecular mechanisms underlying a disease/drug of interest and generates hypotheses. Using ProfileChaser to find correlated profiles, a number of diseases were identified as having an expression profile that is similar to the statin use signature. The strongest correlation was with a Huntin […]
Database of Gene Co Regulation (dGCR): A Web Tool for Analysing Patterns of Gene Co regulation across Publicly Available Expression Data
[…] has been successfully applied in the area of drug repositioning with the connectivity map (CMAP) initiative , and has led to the development of transcription based search engines such as GEM-TREND , ProfileChaser , Gene Expression Atlas and SPIED , , that have thrown up intriguing connections between diverse biological systems. These methodologies are not driven by gene discovery and the pinpoin […]
REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids
[…] Glucocorticoids can induce catabolic/atrophic changes in multiple tissues including muscle, subcutaneous fat, and bone (Wang et al, ; Shimizu et al, ). We used ProfileChaser software to compare transcriptional responses to glucocorticoids in epidermis and other tissues, using our array data and DNA arrays deposited to NCBI (http://profilechaser.stanford.edu, […]
SPIEDw: a searchable platform independent expression database web tool
[…] ines with the objective of mapping drug to disease through direct expression profile correlation . This methodology has been extended to collections of published expression studies in GEM-TREND , ProfileChaser , Gene Expression Atlas  and SPIED . The motivation behind SPIED was in the first place to define expression changes as relative to the average across the experimental series and t […]
Transcriptional data: a new gateway to drug repositioning?
[…] afe’ compounds never linked before to that MoA.Several tools are freely available for mining gene expression data repositories based on similarity with an input signature in a similar manner to cMap. ProfileChaser searches microarray repositories based on genome-wide patterns of differential expression, and MARQ mines GEO for experiments that generate a differential expression profile that is si […]
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