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ProfileChaser specifications


Unique identifier OMICS_04085
Name ProfileChaser
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability No
Maintained No

Publication for ProfileChaser

ProfileChaser citations


The Effect of Statins on Blood Gene Expression in COPD

PLoS One
PMCID: 4604084
PMID: 26462087
DOI: 10.1371/journal.pone.0140022

[…] different diseases, drugs, or perturbations. Concordant expression profiles leads to novel insights into the molecular mechanisms underlying a disease/drug of interest and generates hypotheses. Using ProfileChaser to find correlated profiles, a number of diseases were identified as having an expression profile that is similar to the statin use signature. The strongest correlation was with a Huntin […]


Database of Gene Co Regulation (dGCR): A Web Tool for Analysing Patterns of Gene Co regulation across Publicly Available Expression Data

J Genomics
PMCID: 4303599
PMID: 25628763
DOI: 10.7150/jgen.10888

[…] has been successfully applied in the area of drug repositioning with the connectivity map (CMAP) initiative , and has led to the development of transcription based search engines such as GEM-TREND , ProfileChaser , Gene Expression Atlas and SPIED , , that have thrown up intriguing connections between diverse biological systems. These methodologies are not driven by gene discovery and the pinpoin […]


REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

PMCID: 4309667
PMID: 25504525
DOI: 10.15252/emmm.201404601

[…] Glucocorticoids can induce catabolic/atrophic changes in multiple tissues including muscle, subcutaneous fat, and bone (Wang et al, ; Shimizu et al, ). We used ProfileChaser software to compare transcriptional responses to glucocorticoids in epidermis and other tissues, using our array data and DNA arrays deposited to NCBI (, […]


SPIEDw: a searchable platform independent expression database web tool

BMC Genomics
PMCID: 4046673
PMID: 24199845
DOI: 10.1186/1471-2164-14-765

[…] ines with the objective of mapping drug to disease through direct expression profile correlation []. This methodology has been extended to collections of published expression studies in GEM-TREND [], ProfileChaser [], Gene Expression Atlas [] and SPIED []. The motivation behind SPIED was in the first place to define expression changes as relative to the average across the experimental series and t […]


Transcriptional data: a new gateway to drug repositioning?

Drug Discov Today
PMCID: 3625109
PMID: 22897878
DOI: 10.1016/j.drudis.2012.07.014

[…] afe’ compounds never linked before to that MoA.Several tools are freely available for mining gene expression data repositories based on similarity with an input signature in a similar manner to cMap. ProfileChaser searches microarray repositories based on genome-wide patterns of differential expression, and MARQ mines GEO for experiments that generate a differential expression profile that is si […]


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ProfileChaser institution(s)
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

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