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proFold specifications


Unique identifier OMICS_13638
Name proFold
Interface Web user interface
Restrictions to use None
Input data PDB ID of the protein, the Chain ID of the protein, your e-mail address
Output data Classification result in a “Done list” and sent by e-mail
Computer skills Basic
Stability Stable
Maintained No



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Publication for proFold

proFold citations


Global computational mutagenesis provides a critical stability framework in protein structures

PLoS One
PMCID: 5720693
PMID: 29216252
DOI: 10.1371/journal.pone.0189064

[…] hat these mutations lead to disease. Currently, proteins showing the critical stability framework structures are included as a part into the database of 90 proteins from inherited eye disease ( addition, critical core of protein could be used computationally as an alternative to overcome the score constraint, by using a MSA that creates the alignments based on protein […]


Recent Progress in Machine Learning Based Methods for Protein Fold Recognition

Int J Mol Sci
PMCID: 5187918
PMID: 27999256
DOI: 10.3390/ijms17122118

[…] is developed and freely available at This method is useful to researchers in this field.Moreover, Chen et al. [] recently proposed a recognition method called ProFold. In ProFold, information on protein tertiary structures is first considered in its feature extraction framework in addition to other commonly used features, such as global features of amino ac […]


Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

PMCID: 4848090
PMID: 27058169
DOI: 10.7554/eLife.15075.018
call_split See protocol

[…] a C-terminal TEV (tobacco etch virus protease) cleavable Strep-9xHis tandem affinity tag. Recombinant baculoviruses were generated by co-transfecting transfer vectors with linearised baculovirus DNA (ProFold-ER1, AB vector, San Diego, CA) followed by viral amplification in Spodoptera frugiperda Sf9 cells. The HAESA and SERK1 ectodomains were individually expressed in Trichoplusia ni Tnao38 cells ( […]


Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co Receptor for TLR2

PLoS One
PMCID: 2760212
PMID: 19847289
DOI: 10.1371/journal.pone.0007411

[…] en Bank accession number: GQ227601). The correct mCD36ED DNA sequences were confirmed at each step by sequencing both DNA strands. 2 µg of mCD36ED pAcGP67A plasmid DNA was co-transfected with 2 µg of Profold ER1 baculovirus DNA (AB vector, USA) in Sf-9 cells. After 5 rounds of viral amplification, a titer of 1×109 virus/ml was obtained as determined by an end point dilution assay. Baculovirus infe […]


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proFold institution(s)
College of Information Engineering, Shanghai Maritime University, Shanghai, China; Shanghai University of Medicine & Health Sciences, Shanghai, China
proFold funding source(s)
This work was supported in part by grants from National Natural Science Foundation of China (Grant no. 61303099).

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