PROGgene statistics

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Citations per year

Number of citations per year for the bioinformatics software tool PROGgene

Tool usage distribution map

This map represents all the scientific publications referring to PROGgene per scientific context
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Associated diseases

This word cloud represents PROGgene usage per disease context

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PROGgene specifications


Unique identifier OMICS_12523
Name PROGgene
Alternative names PROGgeneV2, PROGgeneV1
Interface Web user interface
Restrictions to use Academic or non-commercial use
Computer skills Basic
Version 2.0
Stability Stable
Maintained No


This tool is not available anymore.

Publications for PROGgene

PROGgene citations


Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway

Cancer Sci
PMCID: 5891198
PMID: 29377347
DOI: 10.1111/cas.13518

[…] group had shorter overall survival time than patients in the low expression group (log‐rank, P = .017, Figure A) in publicly available gene expression array datasets (TCGA) using prognostic database PROGgene V2. In addition, we found that there was a significant positive correlation between the expression of CD44 and Snail in HCC tissue using data sets from TCGA and GEO (Figure B). Furthermore, w […]


Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas

PMCID: 5862617
PMID: 29568396
DOI: 10.18632/oncotarget.24480

[…] the Genotype-Tissue Expression (GTEx) Project (, which contains data from gene expression microarrays and RNA sequencing.The analysis of PA survival was performed using the ProGgeneV2 Prognostic Database ( []. The Kaplan-Meier survival plots were constructed on in silico data using low-grade glioma survival data from TCGA [TCGA-LGG] […]


Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models

Int J Mol Sci
PMCID: 5855628
PMID: 29385725
DOI: 10.3390/ijms19020406

[…] ent sample types. Statistical significance of the expression differences between groups was determined using Welch’s t-test.To investigate prognostic implications of GLO1 expression, we first queried PROGgeneV2 [] (Available online: GLO1 expression cutoffs at either 25, 50 or 75 percentiles were applied to dichotomize patients into high and low expression gr […]


Profiles of differentially expressed genes and overexpression of NEBL indicates a positive prognosis in patients with colorectal cancer

PMCID: 5783523
PMID: 29257257
DOI: 10.3892/mmr.2017.8210

[…] of identification of the gene transcripts involved in energy metabolism in CRC and the mRNA isoforms used for diagnosis (). Additionally, various databases, such as The Cancer Genome Atlas (TCGA) and PROGgeneV2 also help identify additional, valuable information using the data mining method.In the current study, microarray analysis combined with a protein-protein interaction network was performed […]


Loss of constitutive ABCB1 expression in breast cancer associated with worse prognosis

PMCID: 5479298
PMID: 28670140
DOI: 10.2147/BCTT.S131284
call_split See protocol

[…] Radj) and respective 95% CIs.Survival analyses were also performed by using ABCB1 expression data obtained from publically available gene expression array databases. Two web platforms were evaluated: ProgGeneV2.0, which comprises several independent breast cancer cohorts (only cohorts with at least 200 breast cancer patients were selected), and the Gene Expression Omnibus deposited data (https://w […]


Transcriptome wide analysis of alternative RNA splicing events in Epstein Barr virus associated gastric carcinomas

PLoS One
PMCID: 5426614
PMID: 28493890
DOI: 10.1371/journal.pone.0176880
call_split See protocol

[…] The PROGgeneV2 prognostic biomarker identification tool [] was used to study the implications of splicing factors gene expression on overall survival of GC patients. The preprocessed dataset from TCGA (in […]

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PROGgene institution(s)
Clinical Genomics, Thomas Jefferson University Hospitals, Philadelphia, PA, USA; Department of Surgery, IU School of Medicine, Indianapolis, IN, USA
PROGgene funding source(s)
Partly supported by IUPUI Breast Cancer Signature Center and Susan G. Komen for the Cure grant SAC110025.

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