Provides experimentally determined thermodynamic interaction data between proteins and nucleic acids. ProNIT is useful for researchers wishing to study the underlying mechanisms of protein stability upon mutations and protein-nucleic acid interactions. This online resource contains about 4900 entries from more than 270 research papers. It includes proteins from a variety of organisms, majority of interaction data are from Escherichia coli protein, Mus musculus, or Homo sapiens.
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology (KIT), Iizuka, Japan; Advanced Technology Institute, Inc. (ATI), Saitama, Japan; Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan; Laboratory of Experimental and Computational Biology, NCI, NIH, Frederick, MD, USA; Tsukuba Materials Information Laboratory, Tsukuba, Japan
ProNIT funding source(s)
Partially supported by a Grant-inAid for Publication Scientific Research Results from the Japan Society for the Promotion of Sciences (JSPS).