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PROSITE | A new database containing functional and structural information on PROSITE profiles


Provides a motif descriptor database. PROSITE offers an annotated collection of biologically meaningful motif descriptors dedicated to the identification of protein families and domains. This database uses two kinds of motif descriptors: (i) patterns or regular expressions in which the most significant residue information is discarded, and (ii) generalized profiles and quantitative motif descriptors that consider the overall similarity on the entire length of domains or proteins.

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PROSITE classification

PROSITE specifications

Unique identifier:
Community driven:
User data submission:
Not allowed
Restrictions to use:
Academic or non-commercial use
Data access:
File download, Browse


  • ScanProsite
  • ProRule

PROSITE support


  • Christian J. A. Sigrist <>

Additional information


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SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire (CMU), Geneva, Switzerland; SIB Swiss Institute of Bioinformatics, Vital-IT Group, Quartier Sorge, Lausanne, Switzerland

Funding source(s)

Supported by An FNS project [315230-116864], the Swiss Federal Government through the Federal Office of Education and Science.

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