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Unique identifier OMICS_03061
Name Protegen
Alternative name Protective antigens
Restrictions to use None
Maintained Yes

Publication for Protective antigens

Protegen citations

 (7)
library_books

A Natural Mouse Model for Neisseria Colonization

2018
Infect Immun
PMCID: 5913851
PMID: 29440372
DOI: 10.1128/IAI.00839-17

[…] tidis and N. gonorrhoeae were used to search N. musculi strain AP2031's genome sequence (PubMLST identifier [ID], 29520 []). Many N. meningitidis queries used for the analysis were retrieved from the Protegen protective antigen database (). The accession numbers for the commensal human-dwelling Neisseria genome data used for BLAST searches were as follows: Neisseria polysaccharea ATCC 43768, NZ_AD […]

library_books

Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design

2017
Front Immunol
PMCID: 5662880
PMID: 29123525
DOI: 10.3389/fimmu.2017.01382

[…] study is to systematically analyze known bacterial PAgs reported in the literature and identify underlying design mechanisms for better rational vaccine prediction. Our study uses PAgs collected from Protegen with antigen information and experimental protection evidence manually annotated from peer-reviewed articles (). The significance and association of these Protegen PAgs are analyzed using bio […]

library_books

Computational Identification and Characterization of a Promiscuous T Cell Epitope on the Extracellular Protein 85B of Mycobacterium spp. for Peptide Based Subunit Vaccine Design

2017
Biomed Res Int
PMCID: 5376426
PMID: 28401156
DOI: 10.1155/2017/4826030

[…] Protegen (http://www.violinet.org/protegen/) [], an antigen database and analysis system, was used to assess the antigenicity of Ag85B. For prediction of protective antigens and subunit vaccines, the […]

library_books

Comparative transcriptome profiling approach to glean virulence and immunomodulation related genes of Fasciola hepatica

2015
BMC Genomics
PMCID: 4429430
PMID: 25956885
DOI: 10.1186/s12864-015-1539-8

[…] teins; n = 1,485), obtained from Gagan Garg [,], and a vaccine related pathogen sequence resource, Vaccine Investigation and Online Information Network (Violin; http://www.violinet.org) [], including Protegen (Protective Antigens; n = 350 for nt, n = 591 for protein) [,], VirmugenDB (A Database of Virulent Genes used for Development of Live Attenuated Vaccines; n = 174 for nt, n = 216 for protein) […]

library_books

Genome wide prediction of vaccine targets for human herpes simplex viruses using Vaxign reverse vaccinology

2013
BMC Bioinformatics
PMCID: 3599071
PMID: 23514126
DOI: 10.1186/1471-2105-14-S4-S2

[…] s an integrated component of the web-based VIOLIN database and analysis system (http://www.violinet.org) [], Vaxign can also be improved by interaction with other VIOLIN programs. For example, VIOLIN Protegen is a web-based database that contains over 600 protective antigen information []. These experimentally verified protective antigens can be used for identifying specific patterns in protective […]

library_books

Emerging Vaccine Informatics

2011
PMCID: 3134832
PMID: 21772787
DOI: 10.1155/2010/218590

[…] vaccine adjuvants and vectors, vaccine-induced host immune responses, and vaccine efficacy in host after virulent challenge. VIOLIN curates more than 500 protective antigens (http://www.violinet.org/protegen/) []. Vaccine-related pathogen and host genes are also annotated and available for searching through customized BLAST programs. VIOLIN also stores and processes all possible vaccine literatur […]

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Protegen institution(s)
Unit for Laboratory Animal Medicine, University of Michigan Medical School, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA

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