TANGO
Predicts the aggregation propensities of several disease-related mutations in the Alzheimers b-peptide. TANGO is based on simple physico-chemical principles of secondary structure formation extended by the assumption that the core regions of an aggregate are fully buried. This method offers the possibility to screen large databases for potentially disease-related aggregation motifs as well as to optimize recombinant protein yields by rationally out-designing protein aggregation.