Provides a central resource for the display, search and analysis of structure, function and related annotation for allosteric molecules. A significant expansion to the context and new features such as allosteric sites and allosteric pathways has been released in the current version of ASD. Additionally, the enhanced front-end and back-end of ASD now enable users to efficiently explore the available information about allostery.
Provides data on causality and energetics of allosteric communication. AlloMAPS is an online resource including information obtained with the structure-based statistical mechanical model of allostery (SBSMMA). It contains data on allosteric signaling in three sets of proteins and protein chains: (i) proteins with comprehensively annotated functional and allosteric sites; (ii) protein chains from PDBselect set of chains with low sequence identity; and (iii) proteins with more than 50 known pathological single-nucleotide polymorphisms (SNPs) in each molecule.
Consists in a set of about 90 proteins that have both catalytic and allosteric sites in their structures annotated. CASBench can be used to benchmark catalytic/allosteric pocket detection algorithms, and to study particular proteins with both sites annotated in their structures. The data can be downloaded for a local use or studied on-line using the built-in interactive tools.
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