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Protein ANalysis THrough Evolutionary Relationships PANTHER

A widely used online resource for comprehensive protein evolutionary and functional classification, and includes tools for large-scale biological data analysis. The latest version of PANTHER, 10.0, includes almost 5000 new protein families (for a total of over 12 000 families), each with a reference phylogenetic tree including protein-coding genes from 104 fully sequenced genomes spanning all kingdoms of life. Phylogenetic trees now include inference of horizontal transfer events in addition to speciation and gene duplication events. Functional annotations are regularly updated using the models generated by the Gene Ontology Phylogenetic Annotation Project.

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PANTHER classification

  • Animals
    • Homo sapiens

PANTHER specifications

Web user interface
Computer skills:
Restrictions to use:

PANTHER distribution

PANTHER support


  • Paul D. Thomas <>

Additional information

A R package containing data is available at


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Division of Bioinformatics, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA

Funding source(s)

NHGRI (NIH) [U41HG002273]; NIGMS (NIH) [U24GM088849]

Link to literature

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