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The last decade has seen a remarkable growth in protein databases. This growth comes at a price: a growing number of submitted protein sequences lack functional annotation. Approximately 32% of sequences submitted to the most comprehensive protein database UniProtKB are labelled as 'Unknown protein' or alike.
(Koskinen et al., 2015) PANNZER: high-throughput functional annotation of uncharacterized proteins in an error-prone environment. Bioinformatics.