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Coiled-coil domain detection software tools | Protein structure data analysis

Coiled-coil domain detection software tools | Protein structure data analysis

Coiled-coils refer to a bundle of helices coiled together like strands of a rope. It has been estimated that nearly 3% of protein-encoding regions of genes harbour coiled-coil domains (CCDs). Experimental studies have confirmed that CCDs play a fundamental role in subcellular infrastructure and controlling trafficking of eukaryotic cells. Given the importance of coiled-coils, multiple bioinformatics tools have been developed to facilitate the systematic and high-throughput prediction of CCDs in proteins.

Source text:
(Li et al., 2016) Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins. Brief Bioinform.

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