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Protein residue–residue contact prediction is the problem of predicting whether any two residues in a protein sequence are spatially close to each other in the folded 3D structure. Contacts occurring between sequentially distant residues, i.e. long-range contacts, impose strong constraints on the 3D structure of a protein and are particularly important for structural analyses, understanding the folding process and predicting the 3D structure.
(Di Lena et al., 2012) Deep architectures for protein contact map prediction. Bioinformatics.