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Protein database search software tools | Shotgun metagenomic sequencing data analysis

In metagenomics studies, millions of DNA or cDNA reads are sequenced from environmental samples, and these are then analyzed in an attempt to determine the functional or taxonomic content of the samples (Handelsman et al., 1998). An important computational step is to determine the genes or coding sequences present, which is usually done by aligning the sequences against a reference database of protein sequences. Source text: Huson and Xie, 2014.

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