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Disordered region detection software tools | Protein structure data analysis

Disordered regions are segments of the protein chain which do not adopt stable structures. Such segments are often of interest because they have a close relationship with protein expression and functionality. As such, protein disorder prediction is…
DisProt
Dataset

DisProt Database of Protein Disorder

Annotates protein sequences for intrinsically disorder regions from the…

Annotates protein sequences for intrinsically disorder regions from the literature. DisProt classifies intrinsic disorder based on experimental methods and three ontologies for molecular function,…

IntFOLD
Web

IntFOLD

An independent web server that integrates our leading methods for structure and…

An independent web server that integrates our leading methods for structure and function prediction. The server provides a simple unified interface that aims to make complex protein modelling data…

DisEMBL
Web
Desktop

DisEMBL

A computational tool for prediction of disordered/unstructured regions within a…

A computational tool for prediction of disordered/unstructured regions within a protein sequence.

MFDp
Web

MFDp Multilayered Fusion-based Disorder predictor

Combines per-residue disorder probabilities predicted by MFDp with per-sequence…

Combines per-residue disorder probabilities predicted by MFDp with per-sequence disorder content predicted by DisCon, and applies novel post-processing filters to provide disorder predictions with…

FuzDB
Dataset

FuzDB Fuzzy complexes DataBase

A database of fuzzy protein complexes. FuzDB compiles experimentally observed…

A database of fuzzy protein complexes. FuzDB compiles experimentally observed fuzzy protein complexes, where intrinsic disorder (ID) is maintained upon interacting with a partner (protein, nucleic…

GlobPlot
Web

GlobPlot

A web service that allows the user to plot the tendency within the query…

A web service that allows the user to plot the tendency within the query protein for order/globularity and disorder. GlobPlot successfully identifies inter-domain segments containing linear motifs,…

IUPred
Web

IUPred

Recognizes no single well-defined tertiary structure from the amino acid…

Recognizes no single well-defined tertiary structure from the amino acid sequence based on the estimated pairwise energy content.

PrDOS
Web

PrDOS Protein DisOrder prediction System

A server to predict natively disordered regions of a protein chain from its…

A server to predict natively disordered regions of a protein chain from its amino acid sequence.

DISOPRED
Web

DISOPRED

Allows users to submit a protein sequence, and returns a probability estimate…

Allows users to submit a protein sequence, and returns a probability estimate of each residue in the sequence being disordered. Predicted intrinsically disordered regions (IDRs) are annotated as…

RONN
Web

RONN Regional Order Neural Network

Prediction of natively disordered regions in proteins using a bio-basis…

Prediction of natively disordered regions in proteins using a bio-basis function neural network.

metaPrDOS
Web

metaPrDOS meta Protein DisOrder prediction System

A meta server to predict natively disordered regions of a protein chain from…

A meta server to predict natively disordered regions of a protein chain from its amino acid sequence.

CSpritz
Web

CSpritz

Predicts intrinsic disorder from protein sequences. CSpritz is a web server…

Predicts intrinsic disorder from protein sequences. CSpritz is a web server that uses a combination of three machine learning systems. The software allows the batch prediction of many sequences…

ESpritz
Web

ESpritz

Produce fast and accurate sequence-only predictions, annotating entire genomes…

Produce fast and accurate sequence-only predictions, annotating entire genomes in the order of hours on a single processor core.

UCON
Desktop

UCON Unstructured regions through CONtact maps

Predicts natively unstructured regions through contacts. Ucon is: (i) highly…

Predicts natively unstructured regions through contacts. Ucon is: (i) highly accurate, (ii) quite orthogonal to other methods, and (iii) enables some specific interpretation of the meaning.

MobiDB-lite
Desktop

MobiDB-lite

Uses a single consensus-based prediction to be optimized for highly specific…

Uses a single consensus-based prediction to be optimized for highly specific (i.e. few false positive) predictions of long intrinsic disorder (ID) of protein sequences. MobiDB-lite uses eight…

DISOclust
Web

DISOclust

Provides predictions of protein disorder based on the analysis of 3D structural…

Provides predictions of protein disorder based on the analysis of 3D structural models using ModFOLDclust.

OnD-CRF
Web
PONDR-FIT
Web

PONDR-FIT

A consensus artificial neural network (ANN) prediction method, which was…

A consensus artificial neural network (ANN) prediction method, which was developed by combining the outputs of several individual disorder predictors.

MD
Desktop

MD Meta-Disorder predictor

Molds various sources of information predominantly obtained from orthogonal…

Molds various sources of information predominantly obtained from orthogonal prediction methods. MD is able to (i) detect per-residue, (ii) identify and predict more proteins than other method, and…

disCoP
Web

disCoP Disorder Consensus-based Predictor

This consensus-based method is designed for in-silico prediction of per-residue…

This consensus-based method is designed for in-silico prediction of per-residue protein disorder propensities.

Metadisorder
Web

Metadisorder

An online tool for prediction of protein disorder.

An online tool for prediction of protein disorder.

DisoRDPbind
Web

DisoRDPbind

Predicts the RNA-, DNA-, and protein-binding residues located in the…

Predicts the RNA-, DNA-, and protein-binding residues located in the intrinsically disordered regions. DisoRDPbind is implemented using a runtime-efficient multi-layered design that utilizes…

Proteus
Desktop

Proteus

Predicts the likelihood of a residue to undergo disorder-to-order transition…

Predicts the likelihood of a residue to undergo disorder-to-order transition upon binding to a partner protein. Proteus uses random-forest-based protean predictor. The prediction is based on features…

MobiDB
Dataset

MobiDB

A centralized source aimed at providing the most complete picture on different…

A centralized source aimed at providing the most complete picture on different flavors of disorder in protein structures covering all UniProt sequences (currently over 80 million). The database…

SPOT-disorder
Web

SPOT-disorder Sequence-based Prediction Online Tools for disorder

Develops to be highly effective in predicting both short and long disordered…

Develops to be highly effective in predicting both short and long disordered regions without separated training, despite disordered regions of different sizes having different compositions of amino…

AUCpreD
Web

AUCpreD

A deep learning method for protein disorder prediction. AUCpreD distinguishes…

A deep learning method for protein disorder prediction. AUCpreD distinguishes itself from the others in that it applies a deep probabilistic graphical model DeepCNF to model complex…

DFLpred
Web

DFLpred

A sequence-based predictor of disordered flexible linkers (DFLs). DFLpred…

A sequence-based predictor of disordered flexible linkers (DFLs). DFLpred outputs propensity to form DFLs for each residue in the input sequence. DFLpred uses a small set of empirically selected…

Mollack
Web

Mollack

A web server for the automated construction of unfolded ensembles that uses…

A web server for the automated construction of unfolded ensembles that uses both experimental and molecular simulation data to construct models for the unfolded state. An important aspect of the…

DisBind
Dataset

DisBind

Provides an ultimate resource for functional site classifications in…

Provides an ultimate resource for functional site classifications in intrinsically disordered proteins (IDPs). DisBind is a database dedicated to residue-level classification of functional binding…

PreDisorder
Web

PreDisorder

A fast and reliable server which can be used to predict protein disordered…

A fast and reliable server which can be used to predict protein disordered regions on genomic scale.

CABS-flex
Web

CABS-flex

An efficient procedure for the simulation of structure flexibility of folded…

An efficient procedure for the simulation of structure flexibility of folded globular proteins. Three consecutive steps follow the CABS simulation procedure: (i) structural clustering, (ii) models…

pE-DB
Dataset

pE-DB

Serves as an openly accessible database for the deposition of structural…

Serves as an openly accessible database for the deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of denatured proteins based on nuclear magnetic resonance…

IDEAL
Dataset

IDEAL Intrinsically Disordered proteins with Extensive Annotations and Literature

A collection of intrinsically disordered proteins (IDPs) that cannot adopt…

A collection of intrinsically disordered proteins (IDPs) that cannot adopt stable globular structures under physiological conditions. IDEAL incorporates the interactions of IDPs and their binding…

DisPredict
Desktop

DisPredict DISorder PREdictor

Classifies ordered and disordered residues in a protein sequence with higher…

Classifies ordered and disordered residues in a protein sequence with higher accuracy, specifically in terms of Mathews Correlation Coefficient (MCC) and Area Under the receiver operating…

DIBS
Dataset

DIBS Disordered Binding Site

Provides an extensive collection of interactions formed by a disordered protein…

Provides an extensive collection of interactions formed by a disordered protein region and one or more ordered protein partners. DIBS marks proteins as disordered if a closely homologous protein was…

Mobi
Desktop

Mobi

Annotates full protein sequences. Mobi is a software for the automated…

Annotates full protein sequences. Mobi is a software for the automated identification of ID and mobile regions form PDB structures. This application is able to detect linear interacting peptides…

MFIB
Dataset

MFIB Mutual Folding Induced by Binding

Aims to serve as a starting point for functional and structural analysis of…

Aims to serve as a starting point for functional and structural analysis of interactions between intrinsically Disordered Proteins (IDPs). MFIB is based on the integration of structural and sequence…

Disorder Atlas
Web

Disorder Atlas

Facilitates the interpretation of intrinsic disorder predictions using…

Facilitates the interpretation of intrinsic disorder predictions using proteome-based descriptive statistics. Disorder Atlas is a web-based software that enables a standardized interpretation of…

MoRFCHiBi
Desktop

MoRFCHiBi

A computational approach for fast and accurate prediction of MoRFs in protein…

A computational approach for fast and accurate prediction of MoRFs in protein sequences. MoRFCHiBi combines the outcomes of two SVM models that take advantage of two different kernels with high noise…

IDalign
Web

IDalign

A computational tool to measure the similarity of different disorder curves by…

A computational tool to measure the similarity of different disorder curves by using dynamic programming. This tool is able to identify similar patterns among disorder curves, as well as to present…

D2P2
Dataset

D2P2 Database of Disordered Protein Prediction

A community resource for pre-computed disorder predictions on a large library…

A community resource for pre-computed disorder predictions on a large library of proteins from completely-sequenced genomes. Goals of the database include making statistical comparisons of the…

SLiMFinder
Web

SLiMFinder Short, Linear Motif Finder

A de novo motif discovery tool that identifies statistically over-represented…

A de novo motif discovery tool that identifies statistically over-represented motifs in a set of protein sequences, accounting for the evolutionary relationships between them. Motifs are returned…

DisCons
Desktop
Web

DisCons Disorder Conservation

A pipelined tool that combines the quantification of sequence- and disorder…

A pipelined tool that combines the quantification of sequence- and disorder conservation to classify disordered residue positions. According to this scheme, the most interesting categories (for…

ANCHOR
Web

ANCHOR

Many disordered proteins function via binding to a structured partner and…

Many disordered proteins function via binding to a structured partner and undergo a disorder-to-order transition. In order to predict disordered binding regions, ANCHOR seeks to identify segments…

RAPID
Web
MoRFpred
Web

MoRFpred Molecular Recognition Feature predictor

The server is designed for protein Molecular Recognition Feature (MoRF)…

The server is designed for protein Molecular Recognition Feature (MoRF) prediction. MoRFpred utilizes a novel design in which annotations generated by sequence alignment are fused with predictions…

SLiMPred
Web

SLiMPred Short Linear Motif Predictor

Predicts linear motifs in a protein sequence based on our neural network which…

Predicts linear motifs in a protein sequence based on our neural network which was trained on Short Linear Motif containing proteins. Information about the relative local conservation and the…

x3Disorder
Web

x3Disorder

A tool designed for biologists that attempt to determine the three-dimensional…

A tool designed for biologists that attempt to determine the three-dimensional structure of protein molecules. The function of x3Disorder is to predict the disorder state of each residue of a…

PepBindPred
Desktop

PepBindPred

A software tool for users interested in identifying peptide binding regions…

A software tool for users interested in identifying peptide binding regions within a protein sequence, which may bind to a known protein structure. PepBindPred was trained on a set of non-redundant…

VSL
Desktop
Web

VSL

Two predictors to solve the length-dependency problem in prediction of…

Two predictors to solve the length-dependency problem in prediction of intrinsic protein disorder, i.e. that the amino acid compositions and sequence properties may vary among disordered regions of…

DICHOT
Dataset

DICHOT

Assigns structural domains and un-structural (intrinsically disordered/natively…

Assigns structural domains and un-structural (intrinsically disordered/natively unfolded) regions with a combination of structural assignments and disorder predictions. DICHOT divides sequences into…

FoldIndex
Web

FoldIndex

A web app to predict protein disorder. Metadisorder is a meta method which…

A web app to predict protein disorder. Metadisorder is a meta method which means that it tries to calculate "consensus" from results returned by other methods, consisting in 4 parts:…

DeepCNF
Desktop

DeepCNF

Uses for protein order/disorder prediction. DeepCNF captures long-range…

Uses for protein order/disorder prediction. DeepCNF captures long-range sequence information by a deep hierarchical architecture and exploits interdependency between adjacent order/disorder labels,…

DisoMCS
Desktop

DisoMCS Disorder MCS

A predictor of protein intrinsically disordered regions. The DisoMCS bases on…

A predictor of protein intrinsically disordered regions. The DisoMCS bases on an original multi-class conservative score (MCS) obtained by sequence-order/disorder alignment. Initially, near-disorder…

POODLE-I
Web

POODLE-I POODLE Integration

An efficient web-app for detecting disordered regions in proteins solely from…

An efficient web-app for detecting disordered regions in proteins solely from the amino acid sequence. POODLE-I integrates prediction results obtained from three kinds of disordered region predictors…

DNdisorder
Web

DNdisorder

A sequence based approach for the prediction of protein disorder. The method…

A sequence based approach for the prediction of protein disorder. The method uses boosted ensembles of deep networks to make predictions and participated in the CASP10 experiment.

MFSPSSMpred
Web
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