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Interactions between proteins and DNA play key roles in many biological processes. Gene regulation and transcription, chromatin formation and organization, as well as DNA replication, repair and recombination are driven by proteins that bind DNA through various mechanisms and at varying levels of binding specificity. Through the structural analysis of proteins bound to DNA binding sites, researchers gain insight into the physical mechanisms that underlie protein biological functions.
(Sagendorf et al., 2017) DNAproDB: an interactive tool for structural analysis of DNA-protein complexes. Nucleic Acids Res.