Allows easy, universal discovery of new target proteins, as well as understanding the features underlying different high-level protein functions. ProFET extracts hundreds of features covering the elementary biophysical and sequence derived attributes. Most features capture statistically informative patterns. In addition, different representations of sequences and the amino acids (AA) alphabet provide a compact, compressed set of features. The results from ProFET were incorporated in data analysis pipelines, implemented in python, and adapted for multi-genome scale analysis.